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Leukemic stem cells: clone wars
Affiliations- Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, Poland
open access
Abstract
Leukemic stem cells arise as the effect of mutations of normal hematopoietic cells and overgrow normal hematopoietic tissue. They may also infiltrate other organs. While they begin their life from mutations, they continue to mutate, creating daughter leukemic stem cells that harbor two, three, or more mutations, and these mutations can be different in different daughter stem cells of the same parental line in the same individual. These daughter stem cells then compete between themselves as to which one will overgrow the host tissues with its progeny, and finally will contribute to the host’s death. This process can be shaped by therapy, which may preferentially eliminate some subclones and simultaneously favor others. To eliminate such stem cells, therapy is needed that will preferentially attack their self-renewal.
Abstract
Leukemic stem cells arise as the effect of mutations of normal hematopoietic cells and overgrow normal hematopoietic tissue. They may also infiltrate other organs. While they begin their life from mutations, they continue to mutate, creating daughter leukemic stem cells that harbor two, three, or more mutations, and these mutations can be different in different daughter stem cells of the same parental line in the same individual. These daughter stem cells then compete between themselves as to which one will overgrow the host tissues with its progeny, and finally will contribute to the host’s death. This process can be shaped by therapy, which may preferentially eliminate some subclones and simultaneously favor others. To eliminate such stem cells, therapy is needed that will preferentially attack their self-renewal.
Keywords
stem cells, self-renewal, oncogenic mutations
About this articleTitle
Leukemic stem cells: clone wars
Journal
Issue
Article type
Review article
Pages
268-271
Published online
2021-08-31
Page views
127
Article views/downloads
177
DOI
10.5603/AHP.2021.0052
Bibliographic record
Acta Haematol Pol 2021;52(4):268-271.
Keywords
stem cells
self-renewal
oncogenic mutations
Authors
Wiesław Wiktor Jędrzejczak
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