Alloantibodies anti-C after hematopoietic stem cell transplantation

Abstract

After multiple transfusions of blood components the patient produced alloantibodies anti-C from the Rh blood group system. These antibodies were the reason of the lack of compatibility of red blood cells of donor's hematopoietic stem cells. After allogeneic hematopoietic stem cell transplantation (allo-HSCT) the presence of anti-C from the Rh group was observed, which may indicate production of these antibodies by residual donor lymphocytes. The presence of anti-c, and subsequently anti-C was the reason of difficulties in the process of matching appropriate red cell concentrate (RCC).