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Alloantibodies anti-C after hematopoietic stem cell transplantation
Affiliations- Regionalne Centrum Krwiodawstwa i Krwiolecznictwa im. prof. dr hab. Tadeusza Dorobisza we Wrocławiu, kierownik: Krzysztof Dworak, Wrocław, Polska
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Abstract
After multiple transfusions of blood components the patient produced alloantibodies anti-C from the Rh blood group system. These antibodies were the reason of the lack of compatibility of red blood cells of donor's hematopoietic stem cells. After allogeneic hematopoietic stem cell transplantation (allo-HSCT) the presence of anti-C from the Rh group was observed, which may indicate production of these antibodies by residual donor lymphocytes. The presence of anti-c, and subsequently anti-C was the reason of difficulties in the process of matching appropriate red cell concentrate (RCC).
Abstract
After multiple transfusions of blood components the patient produced alloantibodies anti-C from the Rh blood group system. These antibodies were the reason of the lack of compatibility of red blood cells of donor's hematopoietic stem cells. After allogeneic hematopoietic stem cell transplantation (allo-HSCT) the presence of anti-C from the Rh group was observed, which may indicate production of these antibodies by residual donor lymphocytes. The presence of anti-c, and subsequently anti-C was the reason of difficulties in the process of matching appropriate red cell concentrate (RCC).
Keywords
HSCT; Antibody; Transfusion
About this articleTitle
Alloantibodies anti-C after hematopoietic stem cell transplantation
Journal
Issue
Pages
26-28
Published online
2016-01-01
DOI
10.1016/j.achaem.2015.11.001
Bibliographic record
Acta Haematol Pol 2016;47(1):26-28.
Keywords
HSCT
Antibody
Transfusion
Authors
Lucyna Pawelec-Marzec
Małgorzata Szymczyk-Nużka