open access

Vol 47, No 1 (2016)
Prace oryginalne / Original research articles
Submitted: 2015-07-16
Published online: 2016-01-01
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Elevated factor VIII activity and venous thromboembolism in patients referred to the Iranian Blood Transfusion Organization: A case control study

Seyed Mohammad Tabatabaei1, Seyed Mehdi Sajjadi2, Minoo Ahmadi Nejad1, Farzaneh Tavasoli1, Azita Azarkeivan1
DOI: 10.1016/j.achaem.2016.01.001
·
Acta Haematol Pol 2016;47(1):15-18.
Affiliations
  1. Iranian Blood Transfusion Organization Research Center, Tehran, Iran
  2. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Birjand University of Medical Sciences, Birjand, Iran

open access

Vol 47, No 1 (2016)
Prace oryginalne / Original research articles
Submitted: 2015-07-16
Published online: 2016-01-01

Abstract

Objective

A high plasma level of factor eight (FVIII) is a risk factor for venous thromboembolism (VTE). Since, there was no report about the association of elevated FVIII and VTE in Iranian population, the incidence of elevated FVIII and its association to VTE was evaluated.

Materials and methods

152 consecutive idiopathic VTE patients referred to the Iranian Blood Transfusion Organization (IBTO) and 130 healthy matched blood donors were studied. At least one confirmed idiopathic deep vein thrombosis (DVT) or pulmonary embolism (PE) was found among all cases. The blood samples were collected at least 3 months after DVT/PE diagnosis. The normal reference range was determined by using the Control samples of the donors. FVIII levels were measured using PTT based one-staged assay.

Results

The FVIII levels in the cases and controls were 157.3±53.4 and 111.8±29.7, respectively. In cases, the lowest and the highest levels of FVIII were 66IU/dl and 364IU/dl, while they were 42IU/dl and 195IU/dl for the controls.

There was no relation between gender, age and FVIII level in either group. The normal reference range for the controls was 52–171IU/dl. Considering the cut-off point as 180IU/dl, the elevated values were seen in 28.9% of the case group vs. 3.1% of the control group.

Conclusion

Elevated factor VIII is likely to be a risk factor for VTE. Moreover, a new normal reference range for the Iranian population was defined.

Abstract

Objective

A high plasma level of factor eight (FVIII) is a risk factor for venous thromboembolism (VTE). Since, there was no report about the association of elevated FVIII and VTE in Iranian population, the incidence of elevated FVIII and its association to VTE was evaluated.

Materials and methods

152 consecutive idiopathic VTE patients referred to the Iranian Blood Transfusion Organization (IBTO) and 130 healthy matched blood donors were studied. At least one confirmed idiopathic deep vein thrombosis (DVT) or pulmonary embolism (PE) was found among all cases. The blood samples were collected at least 3 months after DVT/PE diagnosis. The normal reference range was determined by using the Control samples of the donors. FVIII levels were measured using PTT based one-staged assay.

Results

The FVIII levels in the cases and controls were 157.3±53.4 and 111.8±29.7, respectively. In cases, the lowest and the highest levels of FVIII were 66IU/dl and 364IU/dl, while they were 42IU/dl and 195IU/dl for the controls.

There was no relation between gender, age and FVIII level in either group. The normal reference range for the controls was 52–171IU/dl. Considering the cut-off point as 180IU/dl, the elevated values were seen in 28.9% of the case group vs. 3.1% of the control group.

Conclusion

Elevated factor VIII is likely to be a risk factor for VTE. Moreover, a new normal reference range for the Iranian population was defined.

Get Citation

Keywords

Elevated factor VIII; Venous thromboembolism; Iranian population

About this article
Title

Elevated factor VIII activity and venous thromboembolism in patients referred to the Iranian Blood Transfusion Organization: A case control study

Journal

Acta Haematologica Polonica

Issue

Vol 47, No 1 (2016)

Pages

15-18

Published online

2016-01-01

Page views

167

Article views/downloads

180

DOI

10.1016/j.achaem.2016.01.001

Bibliographic record

Acta Haematol Pol 2016;47(1):15-18.

Keywords

Elevated factor VIII
Venous thromboembolism
Iranian population

Authors

Seyed Mohammad Tabatabaei
Seyed Mehdi Sajjadi
Minoo Ahmadi Nejad
Farzaneh Tavasoli
Azita Azarkeivan

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