open access
Central nervous system involvement during clinical course of chronic lymphocytic leukaemia
Affiliations- Katedra i Klinika Hematoonkologii i Transplantacji Szpiku UM w Lublinie, Polska
- Klinika Neurochirurgii i Neurochirurgii Dziecięcej UM w Lublinie, Polska
open access
Abstract
Central nervous system involvement (CNS) of chronic lymphocytic leukemia (CLL) is a rare complication. Some analyses of autopsy studies suggest that the complication remains subclinical or is under-diagnosed. The symptoms of patients with leukemic CNS involvement are heterogeneous and nonspecific. Due to the low incidence, there are no treatment guidelines for this problem. Intrathecal chemotherapy and cranial irradiation are often performed.
Abstract
Central nervous system involvement (CNS) of chronic lymphocytic leukemia (CLL) is a rare complication. Some analyses of autopsy studies suggest that the complication remains subclinical or is under-diagnosed. The symptoms of patients with leukemic CNS involvement are heterogeneous and nonspecific. Due to the low incidence, there are no treatment guidelines for this problem. Intrathecal chemotherapy and cranial irradiation are often performed.
Keywords
Central nervous system; Chronic lymphocytic leukemia; Leukemic infiltration
About this articleTitle
Central nervous system involvement during clinical course of chronic lymphocytic leukaemia
Journal
Issue
Pages
10-14
Published online
2016-01-01
DOI
10.1016/j.achaem.2016.01.002
Bibliographic record
Acta Haematol Pol 2016;47(1):10-14.
Keywords
Central nervous system
Chronic lymphocytic leukemia
Leukemic infiltration
Authors
Ewa Wąsik-Szczepanek
Dariusz Szczepanek
Małgorzata Wach
Marek Hus