Vol 47, No 1 (2016)
Prace poglądowe / Reviews
Published online: 2016-01-01

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Central nervous system involvement during clinical course of chronic lymphocytic leukaemia

Ewa Wąsik-Szczepanek1, Dariusz Szczepanek2, Małgorzata Wach1, Marek Hus1
DOI: 10.1016/j.achaem.2016.01.002
Acta Haematol Pol 2016;47(1):10-14.

Abstract

Central nervous system involvement (CNS) of chronic lymphocytic leukemia (CLL) is a rare complication. Some analyses of autopsy studies suggest that the complication remains subclinical or is under-diagnosed. The symptoms of patients with leukemic CNS involvement are heterogeneous and nonspecific. Due to the low incidence, there are no treatment guidelines for this problem. Intrathecal chemotherapy and cranial irradiation are often performed.

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