open access

Vol 48, No 4 (2017)
Prace poglądowe / Reviews
Published online: 2017-10-01
Submitted: 2016-08-21
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Methods for detection of microparticles derived from blood and endothelial cells

Małgorzata Gradziuk1, Piotr Radziwon2
DOI: 10.1016/j.achaem.2017.03.003
·
Acta Haematol Pol 2017;48(4):316-329.
Affiliations
  1. John Paul II Regional Blood Donation and Transfusion Center in Słupsk, 21 Szarych Szeregów St., 76-200 Słupsk, Poland
  2. Regional Blood Donation and Transfusion Center in Białystok, 23 Marii Skłodowskiej-Curie St., 15-950 Białystok, Poland

open access

Vol 48, No 4 (2017)
Prace poglądowe / Reviews
Published online: 2017-10-01
Submitted: 2016-08-21

Abstract

Microparticles (MP-microparticles) – cell membrane vesicles 0.1–1μm diameter, released in response to activation or apoptosis, both in physiological and pathological conditions. They reveal a wide spectrum of biological activities, express cell surface antigens characteristic for cells of their origin. In this article reviewed quantitative and qualitative methods for detection of microparticles, presents pre-analytical conditions as an potential source of variability in the analysis of MP. In conclusion there are several methods for detection of microparticles but they are not standarized. Methods of microparticles detection need to be standarized to be clinically relevant.

Abstract

Microparticles (MP-microparticles) – cell membrane vesicles 0.1–1μm diameter, released in response to activation or apoptosis, both in physiological and pathological conditions. They reveal a wide spectrum of biological activities, express cell surface antigens characteristic for cells of their origin. In this article reviewed quantitative and qualitative methods for detection of microparticles, presents pre-analytical conditions as an potential source of variability in the analysis of MP. In conclusion there are several methods for detection of microparticles but they are not standarized. Methods of microparticles detection need to be standarized to be clinically relevant.

Get Citation

Keywords

Microparticles; Methods of microparticles detection; Standarization; Pre-analytics

About this article
Title

Methods for detection of microparticles derived from blood and endothelial cells

Journal

Acta Haematologica Polonica

Issue

Vol 48, No 4 (2017)

Pages

316-329

Published online

2017-10-01

DOI

10.1016/j.achaem.2017.03.003

Bibliographic record

Acta Haematol Pol 2017;48(4):316-329.

Keywords

Microparticles
Methods of microparticles detection
Standarization
Pre-analytics

Authors

Małgorzata Gradziuk
Piotr Radziwon

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