Vol 47, No 4 (2016)
Kazuistyka / Case reports
Published online: 2016-10-01

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Transfusion-associated graft-vs-host disease – A case report

Jina Bhattacharyya1, Nilom Khound2, Bhaskar Jyoti Kakati2, Mrinal Bhattacharyya2, Sangit Dutta3, Aishwarya Raj1
DOI: 10.1016/j.achaem.2016.10.005
Acta Haematol Pol 2016;47(4):254-257.


Transfusion-associated graft-vs-host disease (TAGVHD) is a rare complication of blood transfusion. Unlike GVHD associated with hematopoietic stem cell transplantation TA-GVHD involves the patient's bone marrow and leads to bone marrow aplasia. We report a case of TA-GVHD in a 45-year-old post-hysterectomy patient after packed red blood cell transfusion from a sibling donor. The patient had fever, maculopapular rashes all over the body, elevated transaminases, and hyperglycemia after a week of the blood transfusion. Severe pancytopenia and bone marrow aplasia followed and she succumbed to her disease after 3 weeks of onset.

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