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Transfusion-associated graft-vs-host disease – A case report
Affiliations- Department of Clinical Hematology, Gauhati Medical College, Guwahati, India
- International Hospital, Guwahati, India
- Department of Medicine, Gauhati Medical College, Guwahati, India
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Abstract
Transfusion-associated graft-vs-host disease (TAGVHD) is a rare complication of blood transfusion. Unlike GVHD associated with hematopoietic stem cell transplantation TA-GVHD involves the patient's bone marrow and leads to bone marrow aplasia. We report a case of TA-GVHD in a 45-year-old post-hysterectomy patient after packed red blood cell transfusion from a sibling donor. The patient had fever, maculopapular rashes all over the body, elevated transaminases, and hyperglycemia after a week of the blood transfusion. Severe pancytopenia and bone marrow aplasia followed and she succumbed to her disease after 3 weeks of onset.
Abstract
Transfusion-associated graft-vs-host disease (TAGVHD) is a rare complication of blood transfusion. Unlike GVHD associated with hematopoietic stem cell transplantation TA-GVHD involves the patient's bone marrow and leads to bone marrow aplasia. We report a case of TA-GVHD in a 45-year-old post-hysterectomy patient after packed red blood cell transfusion from a sibling donor. The patient had fever, maculopapular rashes all over the body, elevated transaminases, and hyperglycemia after a week of the blood transfusion. Severe pancytopenia and bone marrow aplasia followed and she succumbed to her disease after 3 weeks of onset.
Keywords
Transfusion-associated graft-vs-host disease; One way HLA matching; Hematopoietic stem cell transplantation
About this articleTitle
Transfusion-associated graft-vs-host disease – A case report
Journal
Issue
Pages
254-257
Published online
2016-10-01
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121
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123
DOI
10.1016/j.achaem.2016.10.005
Bibliographic record
Acta Haematol Pol 2016;47(4):254-257.
Keywords
Transfusion-associated graft-vs-host disease
One way HLA matching
Hematopoietic stem cell transplantation
Authors
Jina Bhattacharyya
Nilom Khound
Bhaskar Jyoti Kakati
Mrinal Bhattacharyya
Sangit Dutta
Aishwarya Raj