open access

Vol 47, No 2 (2016)
Prace poglądowe / Reviews
Submitted: 2016-03-29
Published online: 2016-04-01
Get Citation

Immune checkpoint inhibitors as drugs or drug candidates in neoplastic diseases

Aleksandra Mędra1, Agata Majchrzak1, Piotr Smolewski
DOI: 10.1016/j.achaem.2016.04.008
·
Acta Haematol Pol 2016;47(2):155-162.
Affiliations
  1. Zakład Hematologii Doświadczalnej Uniwersytetu Medycznego w Łodzi, Polska

open access

Vol 47, No 2 (2016)
Prace poglądowe / Reviews
Submitted: 2016-03-29
Published online: 2016-04-01

Abstract

Despite of great progress in anti-neoplastic treatment the several solid tumors and hematologic malignancies still remain incurable. Immune system remains under control of several controlling mechanism. Genetic or epigenetic changes in neoplastic cells provide antigen-derived diversity; however, these cells do not initiate immune response. The main mechanism of development of immune resistance by tumor cells seems to be a change in expression of proteins engaged in the immune control point. Immunotherapy with immune checkpoint inhibitors has emerged as promising modality of tumors showing response to several antigens, e.g. anti-CTLA-4 or PD1-PDL1 monoclonal antibodies. In this review we demonstrate the state in the field on this modality of anti-neoplastic treatment.

Abstract

Despite of great progress in anti-neoplastic treatment the several solid tumors and hematologic malignancies still remain incurable. Immune system remains under control of several controlling mechanism. Genetic or epigenetic changes in neoplastic cells provide antigen-derived diversity; however, these cells do not initiate immune response. The main mechanism of development of immune resistance by tumor cells seems to be a change in expression of proteins engaged in the immune control point. Immunotherapy with immune checkpoint inhibitors has emerged as promising modality of tumors showing response to several antigens, e.g. anti-CTLA-4 or PD1-PDL1 monoclonal antibodies. In this review we demonstrate the state in the field on this modality of anti-neoplastic treatment.

Get Citation

Keywords

Cell cycle; Inhibitors; Targeted therapy; Checkpoint

About this article
Title

Immune checkpoint inhibitors as drugs or drug candidates in neoplastic diseases

Journal

Acta Haematologica Polonica

Issue

Vol 47, No 2 (2016)

Pages

155-162

Published online

2016-04-01

Page views

172

Article views/downloads

717

DOI

10.1016/j.achaem.2016.04.008

Bibliographic record

Acta Haematol Pol 2016;47(2):155-162.

Keywords

Cell cycle
Inhibitors
Targeted therapy
Checkpoint

Authors

Aleksandra Mędra
Agata Majchrzak
Piotr Smolewski

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., Grupa Via Medica, ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
phone: +48 58 320 94 94, fax: +48 58 320 94 60, e-mail: viamedica@viamedica.pl