open access

Vol 47, No 2 (2016)
Prace poglądowe / Reviews
Published online: 2016-04-01
Submitted: 2016-03-29
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Rare macrophage diseases in adults

Maciej Machaczka12, Monika Klimkowska3
DOI: 10.1016/j.achaem.2016.04.006
·
Acta Haematol Pol 2016;47(2):146-154.
Affiliations
  1. Medical Faculty, University of Rzeszow, Rzeszow, Poland
  2. Hematology Center Karolinska, Karolinska University Hospital Huddinge, Stockholm, Sweden
  3. Department of Clinical Pathology and Cytology, Karolinska University Hospital Huddinge, Stockholm, Sweden

open access

Vol 47, No 2 (2016)
Prace poglądowe / Reviews
Published online: 2016-04-01
Submitted: 2016-03-29

Abstract

Diseases of macrophages are rare entities characterized by the accumulation of macrophages, dendritic cells or monocyte-derived cells in various tissues and organs. This article focuses on macrophage disorders which can be present in adult patients. The review highlights pathogenesis, signs and symptoms, diagnostic criteria and principles of therapy in the most frequent macrophage diseases in adults: hemophagocytic lymphohistiocytosis, Rosai-Dorfman disease, Gaucher disease, Niemann-Pick disease, and Langerhans cell histiocytosis. Since macrophage disorders can be encountered by various medical specialists, basic knowledge of these entities and their diagnostic criteria should be familiar to all physicians, including hematologists.

Abstract

Diseases of macrophages are rare entities characterized by the accumulation of macrophages, dendritic cells or monocyte-derived cells in various tissues and organs. This article focuses on macrophage disorders which can be present in adult patients. The review highlights pathogenesis, signs and symptoms, diagnostic criteria and principles of therapy in the most frequent macrophage diseases in adults: hemophagocytic lymphohistiocytosis, Rosai-Dorfman disease, Gaucher disease, Niemann-Pick disease, and Langerhans cell histiocytosis. Since macrophage disorders can be encountered by various medical specialists, basic knowledge of these entities and their diagnostic criteria should be familiar to all physicians, including hematologists.

Get Citation

Keywords

Hemophagocytic lymphohistiocytosis; Rosai-Dorfman disease; Gaucher disease; Niemann-Pick disease; Langerhans cell histiocytosis

About this article
Title

Rare macrophage diseases in adults

Journal

Acta Haematologica Polonica

Issue

Vol 47, No 2 (2016)

Pages

146-154

Published online

2016-04-01

DOI

10.1016/j.achaem.2016.04.006

Bibliographic record

Acta Haematol Pol 2016;47(2):146-154.

Keywords

Hemophagocytic lymphohistiocytosis
Rosai-Dorfman disease
Gaucher disease
Niemann-Pick disease
Langerhans cell histiocytosis

Authors

Maciej Machaczka
Monika Klimkowska

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