open access

Vol 47, No 2 (2016)
Prace poglądowe / Reviews
Published online: 2016-04-01
Submitted: 2016-03-07
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Metformin: an old drug in new application

Anna Dmoszyńska1, Monika Podhorecka2, Krzysztof Giannopoulos34
DOI: 10.1016/j.achaem.2016.04.001
·
Acta Haematol Pol 2016;47(2):139-145.
Affiliations
  1. Polska Grupa Szpiczakowa, emerytowany profesor Uniwersytety Medycznego w Lublinie
  2. Klinika Hematoonkologii i Transplantacji Szpiku, Uniwersytet Medyczny w Lublinie, Polska
  3. Zakład Hematoonkologii Doświadczalnej Uniwersytet Medyczny w Lublinie, Polska
  4. Oddział Hematologiczny Centrum Onkologii Ziemi Lubelskiej im. św Jana z Dukli, Polska

open access

Vol 47, No 2 (2016)
Prace poglądowe / Reviews
Published online: 2016-04-01
Submitted: 2016-03-07

Abstract

Metformin is a biguanide derivative that was synthesized in the 20's of last century. The main mechanism of action is the ability to inhibit hepatic gluconeogenesis and trigger glucose uptake in skeletal muscles. Metformin is not only an antihyperglycaemic drug but also has protective effects on endothelium cells. In the last decade, many publications displayed that metformin can reduce risk of cancer in diabetic patients and demonstrated a protective effect against certain types of cancer. In this review article, we discuss known mechanisms of metformin anticancer action and its beneficial role as vascular protective and anticancer agent.

Abstract

Metformin is a biguanide derivative that was synthesized in the 20's of last century. The main mechanism of action is the ability to inhibit hepatic gluconeogenesis and trigger glucose uptake in skeletal muscles. Metformin is not only an antihyperglycaemic drug but also has protective effects on endothelium cells. In the last decade, many publications displayed that metformin can reduce risk of cancer in diabetic patients and demonstrated a protective effect against certain types of cancer. In this review article, we discuss known mechanisms of metformin anticancer action and its beneficial role as vascular protective and anticancer agent.

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Keywords

Metformin; Mechanisms of action; Antiproliferative drug

About this article
Title

Metformin: an old drug in new application

Journal

Acta Haematologica Polonica

Issue

Vol 47, No 2 (2016)

Pages

139-145

Published online

2016-04-01

DOI

10.1016/j.achaem.2016.04.001

Bibliographic record

Acta Haematol Pol 2016;47(2):139-145.

Keywords

Metformin
Mechanisms of action
Antiproliferative drug

Authors

Anna Dmoszyńska
Monika Podhorecka
Krzysztof Giannopoulos

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