open access

Vol 45, No 1 (2014)
Prace poglądowe / Reviews
Submitted: 2013-07-05
Published online: 2014-01-01
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Factors determining therapeutic activity of L-asparaginase

Justyna Walenciak, Beata Zalewska-Szewczyk1
DOI: 10.1016/j.achaem.2013.09.001
·
Acta Haematol Pol 2014;45(1):35-40.
Affiliations
  1. Klinika Pediatrii, Onkologii, Hematologii i Diabetologii Uniwersytetu Medycznego w Łodzi, Uniwersytecki Szpital Kliniczny nr 4 im. M. Konopnickiej, Łódź, Polska

open access

Vol 45, No 1 (2014)
Prace poglądowe / Reviews
Submitted: 2013-07-05
Published online: 2014-01-01

Abstract

L-asparaginase (L-asp) is the basis of contemporary protocols used in the treatment of pediatric acute lymphoblastic leukemia and non-Hodgkin lymphomas. The key factor during L-asparaginase treatment is achieving sufficient serum activity of the drug during particular time period. There are several specified factors influencing L-asp activity. One is the preparation of the enzyme and their different pharmacokinetics. The other is L-asparaginase inactivation due to immunological response. The next factor, indirectly affecting L-asp activity, is the expression of asparagine synthetase, which is an enzyme of the opposite function to L-asparaginase.

The least known process is the enzymatic degradation of L-asparaginase by lisosomal cathepsin B and asparaginyl endopeptidase.

Abstract

L-asparaginase (L-asp) is the basis of contemporary protocols used in the treatment of pediatric acute lymphoblastic leukemia and non-Hodgkin lymphomas. The key factor during L-asparaginase treatment is achieving sufficient serum activity of the drug during particular time period. There are several specified factors influencing L-asp activity. One is the preparation of the enzyme and their different pharmacokinetics. The other is L-asparaginase inactivation due to immunological response. The next factor, indirectly affecting L-asp activity, is the expression of asparagine synthetase, which is an enzyme of the opposite function to L-asparaginase.

The least known process is the enzymatic degradation of L-asparaginase by lisosomal cathepsin B and asparaginyl endopeptidase.

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Keywords

Antineoplastic agents; Leukemia; Treatment outcome; Pediatrics

About this article
Title

Factors determining therapeutic activity of L-asparaginase

Journal

Acta Haematologica Polonica

Issue

Vol 45, No 1 (2014)

Pages

35-40

Published online

2014-01-01

Page views

96

Article views/downloads

423

DOI

10.1016/j.achaem.2013.09.001

Bibliographic record

Acta Haematol Pol 2014;45(1):35-40.

Keywords

Antineoplastic agents
Leukemia
Treatment outcome
Pediatrics

Authors

Justyna Walenciak
Beata Zalewska-Szewczyk

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