Vol 45, No 4 (2014)
Prace poglądowe / Reviews
Published online: 2014-10-01

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Indications for hematopoietic stem cell transplantation in children and adolescents – recommendations of the Polish Pediatric Group for Hematopoietic Stem Cell Transplantation in the year 2014

Jacek Wachowiak1, Walentyna Balwierz2, Alicja Chybicka3, Katarzyna Drabko4, Ewa Gorczyńska3, Jolanta Goździk5, Krzysztof Kałwak3, Bernarda Kazanowska3, Jerzy R. Kowalczyk4, Michał Matysiak6, Jan Styczyński7, Marek Ussowicz3, Grażyna Wróbel3, Mariusz Wysocki7
DOI: 10.1016/j.achaem.2014.09.001
Acta Haematol Pol 2014;45(4):301-312.

Abstract

This article presents the current recommendations from the Polish Pediatric Group for Hematopoietic Stem Cell Transplantation concerning the indications for hematopoietic stem cell transplantation (HSCT) in children and adolescents suffering from hematological malignancies, solid tumours, and congenital or acquired non-malignant disorders. Indications for HSCT are established in context of the recent results of conventional treatment, i.e. obtained with non-HSCT strategies; it means transplantation is justifiable exclusively, when it significantly increases individual patient's chances to be cured, despite of the risk of HSCT-related mortality. Hence, due to the advances of non-transplant treatment strategies as well as progress in the field of HSCT the indications for HSCT require to be regularly up-dated. The recommendations presented in this article are based on the current guidelines from the European Group for Blood and Bone Marrow Transplantation (EBMT), including those from the EBMT Pediatric Diseases Working Party and the EBMT Inborn Errors Working Party, and from the international treatment protocols currently applied in the centers of the Polish Pediatric Leukemia/Lymphoma Study Group and Polish Pediatric Solid Tumours Study Group. The recommendations are addressed not only to the Polish pediatric transplant centers, but first of all to the Polish pediatric centers involved in diagnostics and treatment of the malignancies and non-malignant disorders in children and adolescents with non-transplant strategies, because it is their responsibility to identify as soon as possible indications for HSCT and refer patient at the appropriate time to pediatric transplant center.

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