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Mixed phenotype acute leukemia – how to diagnose, how to treat?
Affiliations- Klinika Onkologii, Hematologii i Transplantologii Pediatrycznej UM w Poznaniu, Kierownik: prof. zw. dr hab. Jacek Wachowiak, Poznań, Polska
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Abstract
In 2009, the World Health Organization has published an updated classification of proliferative diseases, whereby biphenotypic acute leukemia and acute bilineal leukemia, which previously were two separate diseases, were replaced by a single name, mixed phenotype acute leukemia (MPAL). Incidence of MPAL is not exactly known and varies in different publications from 0.5 to 5% of all leukemias in children. In these patients genetic disorders are particularly important for both diagnosis and prognosis. However, due to the still unsatisfactory outcome, the main problem remains optimal therapeutic strategy of patients with MPAL. The majority of research points to better outcomes of MPAL treatment with usage of therapeutic programs for the treatment of acute lymphoblastic leukemia (ALL), although the results are worse than in patients with ALL. An attempt to standardize the therapeutic approach and further improve is the project iBFM AMBI2012.
Abstract
In 2009, the World Health Organization has published an updated classification of proliferative diseases, whereby biphenotypic acute leukemia and acute bilineal leukemia, which previously were two separate diseases, were replaced by a single name, mixed phenotype acute leukemia (MPAL). Incidence of MPAL is not exactly known and varies in different publications from 0.5 to 5% of all leukemias in children. In these patients genetic disorders are particularly important for both diagnosis and prognosis. However, due to the still unsatisfactory outcome, the main problem remains optimal therapeutic strategy of patients with MPAL. The majority of research points to better outcomes of MPAL treatment with usage of therapeutic programs for the treatment of acute lymphoblastic leukemia (ALL), although the results are worse than in patients with ALL. An attempt to standardize the therapeutic approach and further improve is the project iBFM AMBI2012.
Keywords
Biphenotypic acute leukemia; Mixed phenotype acute leukemia; Immunophenotype; Treatment
About this articleTitle
Mixed phenotype acute leukemia – how to diagnose, how to treat?
Journal
Issue
Pages
215-221
Published online
2013-07-01
Page views
100
Article views/downloads
1551
DOI
10.1016/j.achaem.2013.07.014
Bibliographic record
Acta Haematol Pol 2013;44(3):215-221.
Keywords
Biphenotypic acute leukemia
Mixed phenotype acute leukemia
Immunophenotype
Treatment
Authors
Benigna Konatkowska
Olga Zając-Spychała
Jacek Wachowiak