open access

Vol 44, No 4 (2013)
Kazuistyka / Case Report
Submitted: 2013-01-01
Published online: 2013-10-01
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Richter's Syndrome manifested as diffuse large B-cell lymphoma of the mandible with lytic lesions and hypercalcemic crisis

Katarzyna Wiśniewska-Piąty1, Grzegorz Helbig, Krzysztof Woźniczka1, Andrzej Frankiewicz1, Joanna Dziaczkowska-Suszek1, Sławomira Kyrcz-Krzemień1
DOI: 10.1016/j.achaem.2013.01.001
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Acta Haematol Pol 2013;44(4):409-412.
Affiliations
  1. Students’ Research Group, Department of Hematology and Bone Marrow Transplantation, Silesian Medical University, Katowice, Poland

open access

Vol 44, No 4 (2013)
Kazuistyka / Case Report
Submitted: 2013-01-01
Published online: 2013-10-01

Abstract

Richter's Syndrome (RS) is a transformation from chronic lymphocytic leukemia (CLL) into more aggressive lymphoma. RS occurs in about 5% of patients with CLL and its clinical outcome is poor. Extranodal involvements of RS may be present in up to 40% of patients and central nervous system manifestation was found to be the most common. Mandibular localization of RS has not been reported so far. There is no established standard treatment for RS. The improvement of survival in RS patients is achievable with intensive anti-lymphoma chemotherapy and subsequent allogeneic stem cell transplantation (alloHSCT) performed in complete remission. Herein we report a female with RS of the right mandible and hypercalcemia was its first clinical manifestation.

Abstract

Richter's Syndrome (RS) is a transformation from chronic lymphocytic leukemia (CLL) into more aggressive lymphoma. RS occurs in about 5% of patients with CLL and its clinical outcome is poor. Extranodal involvements of RS may be present in up to 40% of patients and central nervous system manifestation was found to be the most common. Mandibular localization of RS has not been reported so far. There is no established standard treatment for RS. The improvement of survival in RS patients is achievable with intensive anti-lymphoma chemotherapy and subsequent allogeneic stem cell transplantation (alloHSCT) performed in complete remission. Herein we report a female with RS of the right mandible and hypercalcemia was its first clinical manifestation.

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Keywords

Chronic lymphocytic leukemia; Richter' s Syndrome; Diffuse large B-cell lymphoma; Hypercalcemia; Outcome

About this article
Title

Richter's Syndrome manifested as diffuse large B-cell lymphoma of the mandible with lytic lesions and hypercalcemic crisis

Journal

Acta Haematologica Polonica

Issue

Vol 44, No 4 (2013)

Pages

409-412

Published online

2013-10-01

Page views

177

Article views/downloads

215

DOI

10.1016/j.achaem.2013.01.001

Bibliographic record

Acta Haematol Pol 2013;44(4):409-412.

Keywords

Chronic lymphocytic leukemia
Richter's Syndrome
Diffuse large B-cell lymphoma
Hypercalcemia
Outcome

Authors

Katarzyna Wiśniewska-Piąty
Grzegorz Helbig
Krzysztof Woźniczka
Andrzej Frankiewicz
Joanna Dziaczkowska-Suszek
Sławomira Kyrcz-Krzemień

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