open access

Vol 48, No 3 (2017)
Kazuistyka / Case reports
Published online: 2017-07-01
Submitted: 2017-06-14
Get Citation

Extraneural relapse of medulloblastoma mimicking acute leukemia: A diagnostic challenge in adult patient

Monika Joks1, Maciej Machaczka23, Anna Czyż1, Jolanta Parulska1, Maciej Majcherek14, Jan Bręborowicz5, Grzegorz Dworacki4, Mieczysław Komarnicki1
DOI: 10.1016/j.achaem.2017.08.002
·
Acta Haematol Pol 2017;48(3):217-219.
Affiliations
  1. Department of Hematology and Bone Marrow Transplantation, Poznań University of Medical Sciences, Poznań, Poland
  2. Neurology Clinic with Brain Stroke Sub-Unit, Clinical Hospital No. 2 in Rzeszow, Medical Faculty, University of Rzeszow, Rzeszów, Poland, Lwowska 60, 35-301 Rzeszów, Poland
  3. Hematology Center Karolinska and Department of Medicine at Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
  4. Chair of Clinical Immunology, Poznań University of Medical Sciences, Poznań, Poland
  5. Department of Tumor Pathology, Wielkopolska Center of Oncology, Poznań, Poland

open access

Vol 48, No 3 (2017)
Kazuistyka / Case reports
Published online: 2017-07-01
Submitted: 2017-06-14

Abstract

Medulloblastoma is the most frequent malignant tumor of the central nervous system (CNS) in children, but it can rarely occur in adults. Extraneural relapse of medulloblastoma occurs very rarely and it is usually associated with dismal prognosis. We present a case of young adult with relapsed medulloblastoma with extraneural metastases in the bone marrow and expression of terminal deoxynucleotidyl transferase (TdT) on the malignant cells mimicking acute leukemia. To the best of our knowledge, this is the first report of medulloblastoma exhibiting expression of the TdT in adult. We would like to emphasize that in cases like this, differential diagnosis of anemia and thrombocytopenia in adults should include a consideration of primary or secondary bone marrow involvement by medulloblastoma or other rare malignancy.

Abstract

Medulloblastoma is the most frequent malignant tumor of the central nervous system (CNS) in children, but it can rarely occur in adults. Extraneural relapse of medulloblastoma occurs very rarely and it is usually associated with dismal prognosis. We present a case of young adult with relapsed medulloblastoma with extraneural metastases in the bone marrow and expression of terminal deoxynucleotidyl transferase (TdT) on the malignant cells mimicking acute leukemia. To the best of our knowledge, this is the first report of medulloblastoma exhibiting expression of the TdT in adult. We would like to emphasize that in cases like this, differential diagnosis of anemia and thrombocytopenia in adults should include a consideration of primary or secondary bone marrow involvement by medulloblastoma or other rare malignancy.

Get Citation

Keywords

Medulloblastoma; Acute leukemia; Relapse; Extraneural; Terminal deoxynucleotidyl transferase

About this article
Title

Extraneural relapse of medulloblastoma mimicking acute leukemia: A diagnostic challenge in adult patient

Journal

Acta Haematologica Polonica

Issue

Vol 48, No 3 (2017)

Pages

217-219

Published online

2017-07-01

DOI

10.1016/j.achaem.2017.08.002

Bibliographic record

Acta Haematol Pol 2017;48(3):217-219.

Keywords

Medulloblastoma
Acute leukemia
Relapse
Extraneural
Terminal deoxynucleotidyl transferase

Authors

Monika Joks
Maciej Machaczka
Anna Czyż
Jolanta Parulska
Maciej Majcherek
Jan Bręborowicz
Grzegorz Dworacki
Mieczysław Komarnicki

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl