Danazol – options of usage for the treatment of haematological diseases

Abstract

Danazol is an attenuated synthetic hormone with weak androgenic effects. It has unique properties similar to those of corticosteroids and has a structure related to testosterone and ethisterone. Danazol is widely used for endometriosis and in mammary gland dysplasia treatment. Among the others, it can be also a therapeutical option for patients with autoimmunological disorders, such as immune thrombocytopenic purpura and autoimmune hemolytic anemia. The attempts of danazol therapy in neoplastic hematological proliferations were also reported. In this article we present the literature review of options of danazol usage in hematology.