open access

Vol 48, No 1 (2017)
Prace oryginalne / Original research articles
Published online: 2017-01-01
Submitted: 2016-05-08
Get Citation

Emerging spread of β-thalassemia trait in Nigeria

Olufemi E. Akanni1, Oluwaseyi E. Bamisaye2, Temitope T. Alabi1
DOI: 10.1016/j.achaem.2016.11.003
·
Acta Haematol Pol 2017;48(1):35-39.
Affiliations
  1. Haematology Division, Department of Medical Laboratory Science, College of Health Sciences, Ladoke Akintola University of Technology, P.M.B. 4400, Osogbo, Osun State, Nigeria
  2. Haematology Division, Department of Medical Laboratory Science, College of Medicine & Health Sciences, Afe Babalola University, P.M.B. 5454, Ado – Ekiti, Ekiti State, Nigeria

open access

Vol 48, No 1 (2017)
Prace oryginalne / Original research articles
Published online: 2017-01-01
Submitted: 2016-05-08

Abstract

Background

Chronic anaemia mainly thalassemia and sickle cell anaemia are inherited disorders of haemoglobin. Presently about 7% of the world's populations are carriers of a potentially pathological haemoglobin gene. Sickle cell disease is a common haemoglobinopathy in Nigeria but recently cases of β-thalassemia traits are becoming prominent. This study aimed at screening for β-thalassemia in adults and children with chronic anaemia in Nigeria by assessing the patients’ level of haemoglobin F, haemoglobin A2 and red cell indices.

Materials and methods

Haemoglobin F and HbA2 were determined in the chronic anaemia patients by Alkaline Denaturation Method and Beta-Thal HbA2 Quick Column Procedure respectively. Haemoglobin genotype was determined by Haemoglobin Electrophoresis at alkaline medium while Complete Blood count was estimated using Sysmex KX-2IN Autoanalyser.

Results

The mean HbF, HbA2, HCT, MCV, MCH and MCHC of the children and adults are 2.56±0.46 and 2.45±0.87 (%); 2.05±0.25 and 1.89±0.60 (%); 0.21±0.31 and 0.21±0.36 (L/L); 81.58±12.59 and 78.69±14.11 (fL); 22.74±5.39 and 23.07±7.36 (pg); 27.52±3.84 and 31.23±14.32 (g/l) respectively. Four percent (2 subjects) of each adult and children population had increased HbF level (>1.5%) and HbA2 levels (>2.8%) and these subjects are composed of 2 children with haemoglobin genotype AA and two adult with haemoglobin genotypes SS.

Conclusions

The outcome of this study reiterates the emergence of β-thalassemia traits and iron deficiency anaemia in different parts of Nigeria irrespective of their haemoglobin genotype status. This requires adequate specialized intervention for their diagnosis and treatment. There is therefore the need for subsequent molecular analysis to determine the β-thalassemia genes present in the studied community.

Abstract

Background

Chronic anaemia mainly thalassemia and sickle cell anaemia are inherited disorders of haemoglobin. Presently about 7% of the world's populations are carriers of a potentially pathological haemoglobin gene. Sickle cell disease is a common haemoglobinopathy in Nigeria but recently cases of β-thalassemia traits are becoming prominent. This study aimed at screening for β-thalassemia in adults and children with chronic anaemia in Nigeria by assessing the patients’ level of haemoglobin F, haemoglobin A2 and red cell indices.

Materials and methods

Haemoglobin F and HbA2 were determined in the chronic anaemia patients by Alkaline Denaturation Method and Beta-Thal HbA2 Quick Column Procedure respectively. Haemoglobin genotype was determined by Haemoglobin Electrophoresis at alkaline medium while Complete Blood count was estimated using Sysmex KX-2IN Autoanalyser.

Results

The mean HbF, HbA2, HCT, MCV, MCH and MCHC of the children and adults are 2.56±0.46 and 2.45±0.87 (%); 2.05±0.25 and 1.89±0.60 (%); 0.21±0.31 and 0.21±0.36 (L/L); 81.58±12.59 and 78.69±14.11 (fL); 22.74±5.39 and 23.07±7.36 (pg); 27.52±3.84 and 31.23±14.32 (g/l) respectively. Four percent (2 subjects) of each adult and children population had increased HbF level (>1.5%) and HbA2 levels (>2.8%) and these subjects are composed of 2 children with haemoglobin genotype AA and two adult with haemoglobin genotypes SS.

Conclusions

The outcome of this study reiterates the emergence of β-thalassemia traits and iron deficiency anaemia in different parts of Nigeria irrespective of their haemoglobin genotype status. This requires adequate specialized intervention for their diagnosis and treatment. There is therefore the need for subsequent molecular analysis to determine the β-thalassemia genes present in the studied community.

Get Citation

Keywords

Chronic anaemia; β-Thalassemia; Haemoglobin F; Haemoglobin A2; Iron deficiency anaemia

About this article
Title

Emerging spread of β-thalassemia trait in Nigeria

Journal

Acta Haematologica Polonica

Issue

Vol 48, No 1 (2017)

Pages

35-39

Published online

2017-01-01

DOI

10.1016/j.achaem.2016.11.003

Bibliographic record

Acta Haematol Pol 2017;48(1):35-39.

Keywords

Chronic anaemia
β-Thalassemia
Haemoglobin F
Haemoglobin A2
Iron deficiency anaemia

Authors

Olufemi E. Akanni
Oluwaseyi E. Bamisaye
Temitope T. Alabi

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl