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Viral infections in children undergoing hematopoietic stem cell transplantation: report 2016 of Polish Pediatric Infectious Working Group of Polish Society of Pediatric Oncology and Hematology
Affiliations- Katedra Pediatrii, Hematologii i Onkologii, Szpital Uniwersytecki nr 1, Collegium Medicum, Uniwersytet Mikołaja Kopernika, Kierownik: prof. dr hab. n. med. Mariusz Wysocki, Bydgoszcz, Polska
- Katedra i Klinika Transplantacji Szpiku, Onkologii i Hematologii Dziecięcej, Uniwersytet Medyczny, Kierownik: prof. dr hab. Alicja Chybicka, Wrocław, Polska
- Klinika Onkologii, Hematologii i Transplantologii Pediatrycznej, Uniwersytet Medyczny, Kierownik: prof. dr hab. Jacek Wachowiak, Poznań, Polska
- Klinika Hematologii, Onkologii i Transplantologii Dziecięcej, Uniwersytet Medyczny, Kierownik: prof. dr hab. Jerzy Kowalczyk, Lublin, Polska
- Ośrodek Transplantacji Uniwersyteckiego Szpitala Dziecięcego, Katedra Immunologii i Transplantologii Klinicznej, Uniwersytet Jagielloński Collegium Medicum, Kierownik: dr hab. Jolanta Goździk, Kraków, Polska
- Katedra i Zakład Mikrobiologii, Collegium Medicum, Uniwersytet Mikołaja Kopernika, Kierownik: prof. dr hab. Eugenia Gospodarek-Komkowska, Bydgoszcz, Polska
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Abstract
Background
Polish Pediatric Infectious Working Group of Polish Society of Pediatric Oncology and Hematology continues from 2012 the infections monitoring program in pediatric hematopoietic stem cell transplant (HSCT) and onco-hematology centers.
Objective
Epidemiological analysis of viral infections in children and adolescents undergoing HSCT in pediatric centers in 2012–2013 and 2014–2015.
Methods
Retrospective analysis of viral infections after 650 HSCT in children and adolescents.
Results
An increase in incidence in 2014–2015 was observed (60.6% vs 51.3%; OR=1.5; p=0.035) after allo-HSCT. Cumulative incidence after allo-HSCT (2012–2013 vs. 2014–2015) was: CMV – 28.0% vs. 29.2%, BKV – 18.5% vs. 22.8%, EBV – 15.5% vs. 24.3%, ADV – 9.5% vs. 5.2%, rotavirus – 9.1% vs. 5.6%, VZV – 2.6% vs. 1.1%, influenza – 0.9% vs. 3.4%, HHV6 – 0.9% vs. 1.5%, norovirus – 0% vs. 2.2%, RSV – 0% vs. 1.5%, parainfluenza – 0% vs. 0.7%, and MPV – 0% vs 0.4%. Infections after auto-HSCT occurred in 8 (10.5%) patients between 2012 and 2013 vs. 2 (2.6%) between 2014 and 2015. Cure rate after viral infections has increased (2012–2013 vs. 2014–2015) for: EBV – 90.7% vs. 100%, ADV – 93.8% vs. 100%, BKV – 94.2% vs. 96.8%, CMV – 94.6% vs. 98%, and remained 100% in infections with influenza, VZV, HHV6, rotavirus as well as in parainfluenza, RSV, and MPV. Decrease of deaths rate attributed to viral infections from 6.5% (2012–2013) to 0.7% (2014–2015) was observed after allo-HSCT.
Conclusions
We found epidemiological trends in viral infections after HSCT in children: increase in incidence after allo-HSCT (increase EBV, appearance of CARV) and decrease after auto-HSCT. Decrease of deaths attributed to viral infections was observed in the last period of time.
Abstract
Background
Polish Pediatric Infectious Working Group of Polish Society of Pediatric Oncology and Hematology continues from 2012 the infections monitoring program in pediatric hematopoietic stem cell transplant (HSCT) and onco-hematology centers.
Objective
Epidemiological analysis of viral infections in children and adolescents undergoing HSCT in pediatric centers in 2012–2013 and 2014–2015.
Methods
Retrospective analysis of viral infections after 650 HSCT in children and adolescents.
Results
An increase in incidence in 2014–2015 was observed (60.6% vs 51.3%; OR=1.5; p=0.035) after allo-HSCT. Cumulative incidence after allo-HSCT (2012–2013 vs. 2014–2015) was: CMV – 28.0% vs. 29.2%, BKV – 18.5% vs. 22.8%, EBV – 15.5% vs. 24.3%, ADV – 9.5% vs. 5.2%, rotavirus – 9.1% vs. 5.6%, VZV – 2.6% vs. 1.1%, influenza – 0.9% vs. 3.4%, HHV6 – 0.9% vs. 1.5%, norovirus – 0% vs. 2.2%, RSV – 0% vs. 1.5%, parainfluenza – 0% vs. 0.7%, and MPV – 0% vs 0.4%. Infections after auto-HSCT occurred in 8 (10.5%) patients between 2012 and 2013 vs. 2 (2.6%) between 2014 and 2015. Cure rate after viral infections has increased (2012–2013 vs. 2014–2015) for: EBV – 90.7% vs. 100%, ADV – 93.8% vs. 100%, BKV – 94.2% vs. 96.8%, CMV – 94.6% vs. 98%, and remained 100% in infections with influenza, VZV, HHV6, rotavirus as well as in parainfluenza, RSV, and MPV. Decrease of deaths rate attributed to viral infections from 6.5% (2012–2013) to 0.7% (2014–2015) was observed after allo-HSCT.
Conclusions
We found epidemiological trends in viral infections after HSCT in children: increase in incidence after allo-HSCT (increase EBV, appearance of CARV) and decrease after auto-HSCT. Decrease of deaths attributed to viral infections was observed in the last period of time.
Keywords
Viral infections; Hematopoietic stem cell transplantation; Children; Epidemiology
About this articleTitle
Viral infections in children undergoing hematopoietic stem cell transplantation: report 2016 of Polish Pediatric Infectious Working Group of Polish Society of Pediatric Oncology and Hematology
Journal
Issue
Pages
23-27
Published online
2017-01-01
DOI
10.1016/j.achaem.2016.11.006
Bibliographic record
Acta Haematol Pol 2017;48(1):23-27.
Keywords
Viral infections
Hematopoietic stem cell transplantation
Children
Epidemiology
Authors
Jan Styczyński
Krzysztof Czyżewski
Jowita Frączkiewicz
Małgorzata Salamonowicz
Olga Zając-Spychała
Agnieszka Zaucha-Prażmo
Jolanta Goździk
Patrycja Zalas-Więcek
Magdalena Dziedzic
Krzysztof Kałwak
Ewa Gorczyńska
Alicja Chybicka
Jacek Wachowiak
Jerzy Kowalczyk
Eugenia Gospodarek-Komkowska
Mariusz Wysocki