open access

Vol 47, No 3 (2016)
Prace poglądowe / Reviews
Submitted: 2016-04-06
Published online: 2016-07-01
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Endoplasmic reticulum stress and oxidative stress in acute myeloid leukemia

Justyna Chlebowska123
DOI: 10.1016/j.achaem.2016.07.001
·
Acta Haematol Pol 2016;47(3):197-204.
Affiliations
  1. Laboratorium Medycyny Doświadczalnej Centrum Nowych Technologii Uniwersytetu Warszawskiego, kierownik: dr hab. Dominika Nowis, Warszawa, Polska
  2. Zakład Immunologii Warszawskiego Uniwersytetu Medycznego, kierownik prof. dr hab. Jakub Gołąb, Warszawa, Polska
  3. Zakład Medycyny Genomowej Warszawskiego Uniwersytetu Medycznego, kierownik: prof. dr hab. Krystian Jażdzewski, Warszawa, Polska

open access

Vol 47, No 3 (2016)
Prace poglądowe / Reviews
Submitted: 2016-04-06
Published online: 2016-07-01

Abstract

Use of differentiation-inducing agents (all-trans retinoic acid and arsenic trioxide) that degradate fusion PML-RARα receptor have revolutionized management of acute promyelocytic (APL) leukemia in 2008. However, despite significant advances in the treatment of APL, the cure rates of patients suffering with other acute myeloid leukemia (AML) subtypes are still not satisfying. Abnormal reactive oxygen species levels and constitutive expression of ER stress marker proteins are characteristic of AML. AML patients with activated unfolded protein response and increased ER chaperone levels showed suppressed CEBPα protein expression. CEBPα is an essential transcription factor that regulates multiple aspects of myelopoiesis. Understanding how the unfolded protein response trigger down-regulation of CEBPα and lead to differentiation blockage opens new possibilities for the design of anti-AML therapeutic strategies.

Abstract

Use of differentiation-inducing agents (all-trans retinoic acid and arsenic trioxide) that degradate fusion PML-RARα receptor have revolutionized management of acute promyelocytic (APL) leukemia in 2008. However, despite significant advances in the treatment of APL, the cure rates of patients suffering with other acute myeloid leukemia (AML) subtypes are still not satisfying. Abnormal reactive oxygen species levels and constitutive expression of ER stress marker proteins are characteristic of AML. AML patients with activated unfolded protein response and increased ER chaperone levels showed suppressed CEBPα protein expression. CEBPα is an essential transcription factor that regulates multiple aspects of myelopoiesis. Understanding how the unfolded protein response trigger down-regulation of CEBPα and lead to differentiation blockage opens new possibilities for the design of anti-AML therapeutic strategies.

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Keywords

Acute myeloid leukemia; ER stress; Oxidative stress; Unfolded protein response; Reactive oxygen species; CEBPα

About this article
Title

Endoplasmic reticulum stress and oxidative stress in acute myeloid leukemia

Journal

Acta Haematologica Polonica

Issue

Vol 47, No 3 (2016)

Pages

197-204

Published online

2016-07-01

Page views

264

Article views/downloads

1299

DOI

10.1016/j.achaem.2016.07.001

Bibliographic record

Acta Haematol Pol 2016;47(3):197-204.

Keywords

Acute myeloid leukemia
ER stress
Oxidative stress
Unfolded protein response
Reactive oxygen species
CEBPα

Authors

Justyna Chlebowska

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