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Endoplasmic reticulum stress and oxidative stress in acute myeloid leukemia
Affiliations- Laboratorium Medycyny Doświadczalnej Centrum Nowych Technologii Uniwersytetu Warszawskiego, kierownik: dr hab. Dominika Nowis, Warszawa, Polska
- Zakład Immunologii Warszawskiego Uniwersytetu Medycznego, kierownik prof. dr hab. Jakub Gołąb, Warszawa, Polska
- Zakład Medycyny Genomowej Warszawskiego Uniwersytetu Medycznego, kierownik: prof. dr hab. Krystian Jażdzewski, Warszawa, Polska
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Abstract
Use of differentiation-inducing agents (all-trans retinoic acid and arsenic trioxide) that degradate fusion PML-RARα receptor have revolutionized management of acute promyelocytic (APL) leukemia in 2008. However, despite significant advances in the treatment of APL, the cure rates of patients suffering with other acute myeloid leukemia (AML) subtypes are still not satisfying. Abnormal reactive oxygen species levels and constitutive expression of ER stress marker proteins are characteristic of AML. AML patients with activated unfolded protein response and increased ER chaperone levels showed suppressed CEBPα protein expression. CEBPα is an essential transcription factor that regulates multiple aspects of myelopoiesis. Understanding how the unfolded protein response trigger down-regulation of CEBPα and lead to differentiation blockage opens new possibilities for the design of anti-AML therapeutic strategies.
Abstract
Use of differentiation-inducing agents (all-trans retinoic acid and arsenic trioxide) that degradate fusion PML-RARα receptor have revolutionized management of acute promyelocytic (APL) leukemia in 2008. However, despite significant advances in the treatment of APL, the cure rates of patients suffering with other acute myeloid leukemia (AML) subtypes are still not satisfying. Abnormal reactive oxygen species levels and constitutive expression of ER stress marker proteins are characteristic of AML. AML patients with activated unfolded protein response and increased ER chaperone levels showed suppressed CEBPα protein expression. CEBPα is an essential transcription factor that regulates multiple aspects of myelopoiesis. Understanding how the unfolded protein response trigger down-regulation of CEBPα and lead to differentiation blockage opens new possibilities for the design of anti-AML therapeutic strategies.
Keywords
Acute myeloid leukemia; ER stress; Oxidative stress; Unfolded protein response; Reactive oxygen species; CEBPα
About this articleTitle
Endoplasmic reticulum stress and oxidative stress in acute myeloid leukemia
Journal
Issue
Pages
197-204
Published online
2016-07-01
Page views
171
Article views/downloads
842
DOI
10.1016/j.achaem.2016.07.001
Bibliographic record
Acta Haematol Pol 2016;47(3):197-204.
Keywords
Acute myeloid leukemia
ER stress
Oxidative stress
Unfolded protein response
Reactive oxygen species
CEBPα
Authors
Justyna Chlebowska