Meaning of dipeptidyl-peptidase IV on the haematopoietic cells in multiple myeloma patients undergoing haematopoietic stem cells mobilization

Abstract

Dipeptidyl peptidase IV is a membrane enzyme involved in intracellular interactions governing processes. Proven its effects on engraftment the transplanted allogeneic hematopoietic cells. The aim of this study was to analyze the expression of CD26 in the mobilization of hematopoietic cells for auto-transplantation in multiple myeloma patients. In 30 patients, who, during the 2011–2012, underwent the mobilization of hematopoietic cells, CD26 was determined on CD34 positive cells as well as on lymphocytes, monocytes and granulocytes, before mobilization procedures, as well as on the cells obtained after separation on cell separator. We found a statistically significant increase in the number of mononuclear cells expressing CD26, non-expression of CD26 on granulocytes, both before and during the mobilization procedures. Additionally we found a week expression of CD26 on CD34 positive cells. The obtained results seem to indicate an important role of bone matrix cells expressing CD26 in the process of mobilization of hematopoietic cells in myeloma multiplex patients.