open access

Vol 51, No 4 (2020)
Untitled
Published online: 2020-12-01
Submitted: 2020-06-18
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Clinical characteristics of essential thrombocythemia patients depend on the mutation status

Witold Prejzner, Andrzej Mital, Maria Bieniaszewska, Aleksandra Leszczyńska, Agata Szymańska, Michał Czarnogórski, Andrzej Hellmann
DOI: 10.2478/ahp-2020-0040
·
Acta Haematol Pol 2020;51(4):230-235.

open access

Vol 51, No 4 (2020)
Untitled
Published online: 2020-12-01
Submitted: 2020-06-18

Abstract

The impact of the mutation status on the clinical course and the outcome of essential thrombocythemia (ET) patients has not yet been completely established. A total of 171 patients with diagnosed ET were tested and subsequently grouped, according to their mutation status – Janus Kinase 2 () – 112 patients, calreticulin () – 36 patients, and thrombopoietin receptor () – 5 patients. Moreover, 18 individuals were triple-negative (with non-mutated , , and ). -mutated patients preferentially were male, with higher platelets (PLT) counts (mean PLT = 1 002.3) and lower hemoglobin and hematocrit levels at the diagnosis, compared to the (mean PLT = 933.6), (mean PLT = 940.8) and triple-negative patients (mean PLT = 822.6) ( = 0.0035). The patients with mutated, and the triple-negative ones had a lower risk of arterial and venous thrombosis (3% and 5.6% cases at the time of diagnosis, respectively) than the patients with mutation (7.2%) ( = 0.9210). The overall survival rate did not differ statistically between the groups.

Abstract

The impact of the mutation status on the clinical course and the outcome of essential thrombocythemia (ET) patients has not yet been completely established. A total of 171 patients with diagnosed ET were tested and subsequently grouped, according to their mutation status – Janus Kinase 2 () – 112 patients, calreticulin () – 36 patients, and thrombopoietin receptor () – 5 patients. Moreover, 18 individuals were triple-negative (with non-mutated , , and ). -mutated patients preferentially were male, with higher platelets (PLT) counts (mean PLT = 1 002.3) and lower hemoglobin and hematocrit levels at the diagnosis, compared to the (mean PLT = 933.6), (mean PLT = 940.8) and triple-negative patients (mean PLT = 822.6) ( = 0.0035). The patients with mutated, and the triple-negative ones had a lower risk of arterial and venous thrombosis (3% and 5.6% cases at the time of diagnosis, respectively) than the patients with mutation (7.2%) ( = 0.9210). The overall survival rate did not differ statistically between the groups.

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Keywords

essential thrombocythemia; Array; Array; Array

About this article
Title

Clinical characteristics of essential thrombocythemia patients depend on the mutation status

Journal

Acta Haematologica Polonica

Issue

Vol 51, No 4 (2020)

Pages

230-235

Published online

2020-12-01

DOI

10.2478/ahp-2020-0040

Bibliographic record

Acta Haematol Pol 2020;51(4):230-235.

Keywords

essential thrombocythemia
Array
Array
Array

Authors

Witold Prejzner
Andrzej Mital
Maria Bieniaszewska
Aleksandra Leszczyńska
Agata Szymańska
Michał Czarnogórski
Andrzej Hellmann

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