Vol 51, No 4 (2020)
Published online: 2020-12-01

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Clinical characteristics of essential thrombocythemia patients depend on the mutation status

Witold Prejzner1, Andrzej Mital1, Maria Bieniaszewska1, Aleksandra Leszczyńska1, Agata Szymańska1, Michał Czarnogórski1, Andrzej Hellmann1
DOI: 10.2478/ahp-2020-0040
Acta Haematol Pol 2020;51(4):230-235.


The impact of the mutation status on the clinical course and the outcome of essential thrombocythemia (ET) patients has not yet been completely established. A total of 171 patients with diagnosed ET were tested and subsequently grouped, according to their mutation status – Janus Kinase 2 () – 112 patients, calreticulin () – 36 patients, and thrombopoietin receptor () – 5 patients. Moreover, 18 individuals were triple-negative (with non-mutated , , and ). -mutated patients preferentially were male, with higher platelets (PLT) counts (mean PLT = 1 002.3) and lower hemoglobin and hematocrit levels at the diagnosis, compared to the (mean PLT = 933.6), (mean PLT = 940.8) and triple-negative patients (mean PLT = 822.6) ( = 0.0035). The patients with mutated, and the triple-negative ones had a lower risk of arterial and venous thrombosis (3% and 5.6% cases at the time of diagnosis, respectively) than the patients with mutation (7.2%) ( = 0.9210). The overall survival rate did not differ statistically between the groups.

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