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Clinical characteristics of essential thrombocythemia patients depend on the mutation status
Affiliations- Department of Hematology and Transplantology, Medical University of Gdansk, Poland
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Abstract
The impact of the mutation status on the clinical course and the outcome of essential thrombocythemia (ET) patients has not yet been completely established. A total of 171 patients with diagnosed ET were tested and subsequently grouped, according to their mutation status – Janus Kinase 2 () – 112 patients, calreticulin () – 36 patients, and thrombopoietin receptor () – 5 patients. Moreover, 18 individuals were triple-negative (with non-mutated , , and ). -mutated patients preferentially were male, with higher platelets (PLT) counts (mean PLT = 1 002.3) and lower hemoglobin and hematocrit levels at the diagnosis, compared to the (mean PLT = 933.6), (mean PLT = 940.8) and triple-negative patients (mean PLT = 822.6) ( = 0.0035). The patients with mutated, and the triple-negative ones had a lower risk of arterial and venous thrombosis (3% and 5.6% cases at the time of diagnosis, respectively) than the patients with mutation (7.2%) ( = 0.9210). The overall survival rate did not differ statistically between the groups.
Abstract
The impact of the mutation status on the clinical course and the outcome of essential thrombocythemia (ET) patients has not yet been completely established. A total of 171 patients with diagnosed ET were tested and subsequently grouped, according to their mutation status – Janus Kinase 2 () – 112 patients, calreticulin () – 36 patients, and thrombopoietin receptor () – 5 patients. Moreover, 18 individuals were triple-negative (with non-mutated , , and ). -mutated patients preferentially were male, with higher platelets (PLT) counts (mean PLT = 1 002.3) and lower hemoglobin and hematocrit levels at the diagnosis, compared to the (mean PLT = 933.6), (mean PLT = 940.8) and triple-negative patients (mean PLT = 822.6) ( = 0.0035). The patients with mutated, and the triple-negative ones had a lower risk of arterial and venous thrombosis (3% and 5.6% cases at the time of diagnosis, respectively) than the patients with mutation (7.2%) ( = 0.9210). The overall survival rate did not differ statistically between the groups.
Keywords
essential thrombocythemia; Array; Array; Array
About this articleTitle
Clinical characteristics of essential thrombocythemia patients depend on the mutation status
Journal
Issue
Pages
230-235
Published online
2020-12-01
Page views
180
Article views/downloads
408
DOI
10.2478/ahp-2020-0040
Bibliographic record
Acta Haematol Pol 2020;51(4):230-235.
Keywords
essential thrombocythemia
Array
Array
Array
Authors
Witold Prejzner
Andrzej Mital
Maria Bieniaszewska
Aleksandra Leszczyńska
Agata Szymańska
Michał Czarnogórski
Andrzej Hellmann