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Medical dilemmas – erythrocytosis
Affiliations- Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Szamarzewskiego 84, 60-569 Poznań, Poland
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Abstract
Erythrocytosis is defined not only by an increase in the erythrocyte count, hemoglobin concentration, and hematocrit value, but also by the occurrence of specific symptoms, the intensity and frequency of which depend on the character of the initial genetic lesion. Ischemic episodes and thrombotic complications caused by increased blood viscosity are frequently the first clinical manifestation of the disease. This paper represents the current level of knowledge about the pathogenesis of erythrocytosis and the diagnostic algorithms used to precisely define the type of the disease.
Abstract
Erythrocytosis is defined not only by an increase in the erythrocyte count, hemoglobin concentration, and hematocrit value, but also by the occurrence of specific symptoms, the intensity and frequency of which depend on the character of the initial genetic lesion. Ischemic episodes and thrombotic complications caused by increased blood viscosity are frequently the first clinical manifestation of the disease. This paper represents the current level of knowledge about the pathogenesis of erythrocytosis and the diagnostic algorithms used to precisely define the type of the disease.
Keywords
polycythemia; erythrocytosis; thrombosis; molecular defects; inflammation; therapy
About this articleTitle
Medical dilemmas – erythrocytosis
Journal
Issue
Pages
203-211
Published online
2020-12-01
Page views
253
Article views/downloads
608
DOI
10.2478/ahp-2020-0036
Bibliographic record
Acta Haematol Pol 2020;51(4):203-211.
Keywords
polycythemia
erythrocytosis
thrombosis
molecular defects
inflammation
therapy
Authors
Krzysztof Lewandowski