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Monoclonal gammopathies of undetermined significance and smoldering myeloma
Affiliations- Department of Hematology, Jagiellonian University Medical College, Krakow, Poland
- Health Service Executive, Dublin
- Department of Hematology, Transplantology and Internal Medicine, Warsaw, Poland
- Department of Nephrology, Jagiellonian University Collegium Medicum, Cracow, Poland
- Multiple Myeloma Division, Myeloma Research, John Theurer Cancer Center and Hackensack Meridian School of Medicine, Hackensack
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Abstract
Monoclonal gammopathy of undetermined significance (MGUS) is a clonal plasma cell disorder implicated as a precursor of multiple myeloma (MM), while smoldering multiple myeloma (SMM) is a malignant plasma cell disorder without evidence of a myeloma-defining event(s) (MDE). This is a review article of both disorders outlining their current definition and management according to the current standard of care. We focus on the pathogenesis of MM and the role of MGUS and SMM in the development of active MM. MGUS is a benign disorder and, subsequently, is followed by observation. In contrast, for SMM, although the current standard of care is “watch and wait”, this paper will explore the circumstances in which treatment should be considered to prevent MDE.
Abstract
Monoclonal gammopathy of undetermined significance (MGUS) is a clonal plasma cell disorder implicated as a precursor of multiple myeloma (MM), while smoldering multiple myeloma (SMM) is a malignant plasma cell disorder without evidence of a myeloma-defining event(s) (MDE). This is a review article of both disorders outlining their current definition and management according to the current standard of care. We focus on the pathogenesis of MM and the role of MGUS and SMM in the development of active MM. MGUS is a benign disorder and, subsequently, is followed by observation. In contrast, for SMM, although the current standard of care is “watch and wait”, this paper will explore the circumstances in which treatment should be considered to prevent MDE.
Keywords
monoclonal gammopathy of undetermined significance; multiple myeloma; smoldering multiple myeloma
About this articleTitle
Monoclonal gammopathies of undetermined significance and smoldering myeloma
Journal
Issue
Pages
193-202
Published online
2020-12-01
Page views
253
Article views/downloads
347
DOI
10.2478/ahp-2020-0035
Bibliographic record
Acta Haematol Pol 2020;51(4):193-202.
Keywords
monoclonal gammopathy of undetermined significance
multiple myeloma
smoldering multiple myeloma
Authors
Artur Jurczyszyn
Ruth Hutch
Anna Waszczuk-Gajda
Anna Suska
Katarzyna Krzanowska
David H. Vesole