open access

Vol 51, No 4 (2020)
Untitled
Published online: 2020-12-01
Submitted: 2020-08-04
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Monoclonal gammopathies of undetermined significance and smoldering myeloma

Artur Jurczyszyn, Ruth Hutch, Anna Waszczuk-Gajda, Anna Suska, Katarzyna Krzanowska, David H. Vesole
DOI: 10.2478/ahp-2020-0035
·
Acta Haematol Pol 2020;51(4):193-202.

open access

Vol 51, No 4 (2020)
Untitled
Published online: 2020-12-01
Submitted: 2020-08-04

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) is a clonal plasma cell disorder implicated as a precursor of multiple myeloma (MM), while smoldering multiple myeloma (SMM) is a malignant plasma cell disorder without evidence of a myeloma-defining event(s) (MDE). This is a review article of both disorders outlining their current definition and management according to the current standard of care. We focus on the pathogenesis of MM and the role of MGUS and SMM in the development of active MM. MGUS is a benign disorder and, subsequently, is followed by observation. In contrast, for SMM, although the current standard of care is “watch and wait”, this paper will explore the circumstances in which treatment should be considered to prevent MDE.

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) is a clonal plasma cell disorder implicated as a precursor of multiple myeloma (MM), while smoldering multiple myeloma (SMM) is a malignant plasma cell disorder without evidence of a myeloma-defining event(s) (MDE). This is a review article of both disorders outlining their current definition and management according to the current standard of care. We focus on the pathogenesis of MM and the role of MGUS and SMM in the development of active MM. MGUS is a benign disorder and, subsequently, is followed by observation. In contrast, for SMM, although the current standard of care is “watch and wait”, this paper will explore the circumstances in which treatment should be considered to prevent MDE.

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Keywords

monoclonal gammopathy of undetermined significance; multiple myeloma; smoldering multiple myeloma

About this article
Title

Monoclonal gammopathies of undetermined significance and smoldering myeloma

Journal

Acta Haematologica Polonica

Issue

Vol 51, No 4 (2020)

Pages

193-202

Published online

2020-12-01

DOI

10.2478/ahp-2020-0035

Bibliographic record

Acta Haematol Pol 2020;51(4):193-202.

Keywords

monoclonal gammopathy of undetermined significance
multiple myeloma
smoldering multiple myeloma

Authors

Artur Jurczyszyn
Ruth Hutch
Anna Waszczuk-Gajda
Anna Suska
Katarzyna Krzanowska
David H. Vesole

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