Vol 51, No 4 (2020)
Published online: 2020-12-01

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Monoclonal gammopathies of undetermined significance and smoldering myeloma

Artur Jurczyszyn1, Ruth Hutch23, Anna Waszczuk-Gajda3, Anna Suska1, Katarzyna Krzanowska4, David H. Vesole5
DOI: 10.2478/ahp-2020-0035
Acta Haematol Pol 2020;51(4):193-202.


Monoclonal gammopathy of undetermined significance (MGUS) is a clonal plasma cell disorder implicated as a precursor of multiple myeloma (MM), while smoldering multiple myeloma (SMM) is a malignant plasma cell disorder without evidence of a myeloma-defining event(s) (MDE). This is a review article of both disorders outlining their current definition and management according to the current standard of care. We focus on the pathogenesis of MM and the role of MGUS and SMM in the development of active MM. MGUS is a benign disorder and, subsequently, is followed by observation. In contrast, for SMM, although the current standard of care is “watch and wait”, this paper will explore the circumstances in which treatment should be considered to prevent MDE.

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