open access

Vol 51, No 3 (2020)
ORIGINAL RESEARCH ARTICLE
Submitted: 2020-05-25
Published online: 2020-09-01
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Progress and trends in pediatric hematopoietic cell transplantation in Central-East European countries

Krzysztof Czyżewski1, Petr Sedláček2, Jaroslav Štěrba3, Ernest Bilic45, Jelena Roganović6, Gergely Krivan7, Jelena Rascon8, Anca Colita9, Janez Jazbec10, Peter Švec11, Pavlyk Serhii12, Oleksandr Lysytsia13, Jacek Wachowiak14, Jan Styczyński1
DOI: 10.2478/ahp-2020-0026
·
Acta Haematol Pol 2020;51(3):142-150.
Affiliations
  1. Department of Pediatric Hematology and Oncology, Collegium Medicum, Antoni Jurasz University Hospital in Bydgoszcz, Nicolaus Copernicus University Torun, Bydgoszcz, Poland
  2. Department of Pediatric Hematology and Oncology, Teaching Hospital Motol, 2nd Medical School, Charles University Motol, Czech Republic, Prague
  3. Department of Pediatric Oncology, Faculty of Medicine, University Hospital Brno, Masaryk University, Czech Republic, Brno
  4. Department of Pediatrics, Division of Pediatric Hematology and Oncology, University Hospital Centre, Zagreb, Croatia
  5. Department of Anatomy, School of Medicine, University of Zagreb
  6. Department of Pediatrics, Faculty of Medicine, Clinical Hospital Center Rijeka, University of Rijeka, Rijeka, Croatia
  7. Department of Pediatric Hematology and Hemopoietic Stem Cell Transplantation, Central Hospital of Southern Pest-National Institute of Hematology and Infectious Diseases, Budapest, Hungary
  8. Center of Pediatric Oncology and Hematology, Vilnius University, Vilnius, Lithuania
  9. Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
  10. Department of Pediatrics, Division of Oncology and Hematology, Medical Centre Ljubljana, Ljubljana, Slovenia
  11. Bone Marrow Transplantation Unit, Department of Pediatric Hematology and Oncology, National Institute of Children's Diseases, Comenius University, Bratislava, Slovakia
  12. Department of Children's, National Cancer Institute, Kyiv, Ukraine
  13. National Pediatric Specialized Hospital “OHMATDYT”, Kyiv, Ukraine
  14. Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences

open access

Vol 51, No 3 (2020)
ORIGINAL RESEARCH ARTICLE
Submitted: 2020-05-25
Published online: 2020-09-01

Abstract

Hematopoietic cell transplantation (HCT) is widely used as a treatment for acquired and congenital disorders. In recent years, a significant increase in transplant activity around the world has been observed, especially in Eastern European countries. This article aimed to assess progress and trends in pediatric HCT in Central-Eastern European countries between 2013 and 2018. Transplant activity survey in 2013 and 2018 in nine Central-Eastern European countries (Czech Republic, Croatia, Hungary, Lithuania, Poland, Romania, Slovakia, Slovenia, and Ukraine) was performed. The highest transplant rates in total were found in the Czech Republic and Hungary. When calculated per 10 million of the pediatric population, a 25.9% increase in the number of allo-HCT was observed with the highest in Croatia, Romania, Lithuania, and Poland; and a 12.2% increase in the number of auto-HCT was observed with the highest in Slovenia, Slovakia, Romania, Poland, Ukraine, and Croatia. We have shown, over the years 2013 and 2018, in some countries of Central-Eastern Europe that there was a significant increase in transplant activity, especially in those with the lower rates. This increase was observed mainly in centers already existing in 2013, especially in the allo-HCT setting. The rise of activity was significantly less influenced by the creation of new transplant centers or the increase in the number of pediatric transplant beds. In conclusion, our analysis indicates that in the Czech Republic, Hungary, Lithuania, and Slovenia, the actual infrastructure and the number of HCTs cover the needs, whereas in other countries, especially in Romania and Ukraine, the number of HCT needs to be increased.

Abstract

Hematopoietic cell transplantation (HCT) is widely used as a treatment for acquired and congenital disorders. In recent years, a significant increase in transplant activity around the world has been observed, especially in Eastern European countries. This article aimed to assess progress and trends in pediatric HCT in Central-Eastern European countries between 2013 and 2018. Transplant activity survey in 2013 and 2018 in nine Central-Eastern European countries (Czech Republic, Croatia, Hungary, Lithuania, Poland, Romania, Slovakia, Slovenia, and Ukraine) was performed. The highest transplant rates in total were found in the Czech Republic and Hungary. When calculated per 10 million of the pediatric population, a 25.9% increase in the number of allo-HCT was observed with the highest in Croatia, Romania, Lithuania, and Poland; and a 12.2% increase in the number of auto-HCT was observed with the highest in Slovenia, Slovakia, Romania, Poland, Ukraine, and Croatia. We have shown, over the years 2013 and 2018, in some countries of Central-Eastern Europe that there was a significant increase in transplant activity, especially in those with the lower rates. This increase was observed mainly in centers already existing in 2013, especially in the allo-HCT setting. The rise of activity was significantly less influenced by the creation of new transplant centers or the increase in the number of pediatric transplant beds. In conclusion, our analysis indicates that in the Czech Republic, Hungary, Lithuania, and Slovenia, the actual infrastructure and the number of HCTs cover the needs, whereas in other countries, especially in Romania and Ukraine, the number of HCT needs to be increased.

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Keywords

hematopoietic cell transplantation; children; Central-Eastern European countries

About this article
Title

Progress and trends in pediatric hematopoietic cell transplantation in Central-East European countries

Journal

Acta Haematologica Polonica

Issue

Vol 51, No 3 (2020)

Pages

142-150

Published online

2020-09-01

Page views

122

Article views/downloads

137

DOI

10.2478/ahp-2020-0026

Bibliographic record

Acta Haematol Pol 2020;51(3):142-150.

Keywords

hematopoietic cell transplantation
children
Central-Eastern European countries

Authors

Krzysztof Czyżewski
Petr Sedláček
Jaroslav Štěrba
Ernest Bilic
Jelena Roganović
Gergely Krivan
Jelena Rascon
Anca Colita
Janez Jazbec
Peter Švec
Pavlyk Serhii
Oleksandr Lysytsia
Jacek Wachowiak
Jan Styczyński

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