open access
Progress and trends in pediatric hematopoietic cell transplantation in Central-East European countries
Affiliations- Department of Pediatric Hematology and Oncology, Collegium Medicum, Antoni Jurasz University Hospital in Bydgoszcz, Nicolaus Copernicus University Torun, Bydgoszcz, Poland
- Department of Pediatric Hematology and Oncology, Teaching Hospital Motol, 2nd Medical School, Charles University Motol, Czech Republic, Prague
- Department of Pediatric Oncology, Faculty of Medicine, University Hospital Brno, Masaryk University, Czech Republic, Brno
- Department of Pediatrics, Division of Pediatric Hematology and Oncology, University Hospital Centre, Zagreb, Croatia
- Department of Anatomy, School of Medicine, University of Zagreb
- Department of Pediatrics, Faculty of Medicine, Clinical Hospital Center Rijeka, University of Rijeka, Rijeka, Croatia
- Department of Pediatric Hematology and Hemopoietic Stem Cell Transplantation, Central Hospital of Southern Pest-National Institute of Hematology and Infectious Diseases, Budapest, Hungary
- Center of Pediatric Oncology and Hematology, Vilnius University, Vilnius, Lithuania
- Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
- Department of Pediatrics, Division of Oncology and Hematology, Medical Centre Ljubljana, Ljubljana, Slovenia
- Bone Marrow Transplantation Unit, Department of Pediatric Hematology and Oncology, National Institute of Children's Diseases, Comenius University, Bratislava, Slovakia
- Department of Children's, National Cancer Institute, Kyiv, Ukraine
- National Pediatric Specialized Hospital “OHMATDYT”, Kyiv, Ukraine
- Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences
open access
Abstract
Hematopoietic cell transplantation (HCT) is widely used as a treatment for acquired and congenital disorders. In recent years, a significant increase in transplant activity around the world has been observed, especially in Eastern European countries. This article aimed to assess progress and trends in pediatric HCT in Central-Eastern European countries between 2013 and 2018. Transplant activity survey in 2013 and 2018 in nine Central-Eastern European countries (Czech Republic, Croatia, Hungary, Lithuania, Poland, Romania, Slovakia, Slovenia, and Ukraine) was performed. The highest transplant rates in total were found in the Czech Republic and Hungary. When calculated per 10 million of the pediatric population, a 25.9% increase in the number of allo-HCT was observed with the highest in Croatia, Romania, Lithuania, and Poland; and a 12.2% increase in the number of auto-HCT was observed with the highest in Slovenia, Slovakia, Romania, Poland, Ukraine, and Croatia. We have shown, over the years 2013 and 2018, in some countries of Central-Eastern Europe that there was a significant increase in transplant activity, especially in those with the lower rates. This increase was observed mainly in centers already existing in 2013, especially in the allo-HCT setting. The rise of activity was significantly less influenced by the creation of new transplant centers or the increase in the number of pediatric transplant beds. In conclusion, our analysis indicates that in the Czech Republic, Hungary, Lithuania, and Slovenia, the actual infrastructure and the number of HCTs cover the needs, whereas in other countries, especially in Romania and Ukraine, the number of HCT needs to be increased.
Abstract
Hematopoietic cell transplantation (HCT) is widely used as a treatment for acquired and congenital disorders. In recent years, a significant increase in transplant activity around the world has been observed, especially in Eastern European countries. This article aimed to assess progress and trends in pediatric HCT in Central-Eastern European countries between 2013 and 2018. Transplant activity survey in 2013 and 2018 in nine Central-Eastern European countries (Czech Republic, Croatia, Hungary, Lithuania, Poland, Romania, Slovakia, Slovenia, and Ukraine) was performed. The highest transplant rates in total were found in the Czech Republic and Hungary. When calculated per 10 million of the pediatric population, a 25.9% increase in the number of allo-HCT was observed with the highest in Croatia, Romania, Lithuania, and Poland; and a 12.2% increase in the number of auto-HCT was observed with the highest in Slovenia, Slovakia, Romania, Poland, Ukraine, and Croatia. We have shown, over the years 2013 and 2018, in some countries of Central-Eastern Europe that there was a significant increase in transplant activity, especially in those with the lower rates. This increase was observed mainly in centers already existing in 2013, especially in the allo-HCT setting. The rise of activity was significantly less influenced by the creation of new transplant centers or the increase in the number of pediatric transplant beds. In conclusion, our analysis indicates that in the Czech Republic, Hungary, Lithuania, and Slovenia, the actual infrastructure and the number of HCTs cover the needs, whereas in other countries, especially in Romania and Ukraine, the number of HCT needs to be increased.
Keywords
hematopoietic cell transplantation; children; Central-Eastern European countries
About this articleTitle
Progress and trends in pediatric hematopoietic cell transplantation in Central-East European countries
Journal
Issue
Pages
142-150
Published online
2020-09-01
Page views
210
Article views/downloads
229
DOI
10.2478/ahp-2020-0026
Bibliographic record
Acta Haematol Pol 2020;51(3):142-150.
Keywords
hematopoietic cell transplantation
children
Central-Eastern European countries
Authors
Krzysztof Czyżewski
Petr Sedláček
Jaroslav Štěrba
Ernest Bilic
Jelena Roganović
Gergely Krivan
Jelena Rascon
Anca Colita
Janez Jazbec
Peter Švec
Pavlyk Serhii
Oleksandr Lysytsia
Jacek Wachowiak
Jan Styczyński