Vol 51, No 2 (2020)
Published online: 2020-06-01

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Parameters of tissue iron overload and cardiac function in patients with thalassemia major and intermedia

Sarah Safniyat1, Nader Shakibazad23, Sezaneh Haghpanah2, Hamid Amoozegar4, Mehran Karimi2, Sanaz Safaei5, Saeed Safniyat6, Hamid Mohammadi4, Omid Reza Zekavat2
DOI: 10.2478/ahp-2020-0018
Acta Haematol Pol 2020;51(2):95-101.



Noninvasive T2* magnetic resonance imaging (MRI) assessment can stratify the risk of subsequent cardiac dysfunction in β-thalassemia major (TM) and β-thalassemia intermedia (TI) patients. The normal level of N-terminal pro B-type natriuretic peptides (NT-proBNP) can rule out acute heart failure.


We aim to investigate the relation of NT-proBNP level, T2* MRI, and echocardiographic findings in TM and TI patients.

Materials and methods

In this cross-sectional study, 41 TM patients, 41 TI patients, and 41 healthy individuals (HI) were enrolled. NT-proBNP level, T2* MRI, and two-dimensional echocardiography were assessed for all patients and controls.


There was statistically significant correlation between NT-proBNP levels and mitral inflow late diastolic velocity ( = −0.538; = 0.006) in TM group. There was statistically significant correlation between NT-proBNP levels and tricuspid annulus systolic velocity ( = −0.438; = 0.028), systolic velocity of septum ( = −0.472; = 0.020), and mitral inflow early-to-late diastolic wave ratio ( = 0.592; = 0.002) in TM group.


Early diagnosis and treatment of myocardial iron overload are likely to prevent the mortality in patients with established ventricular dysfunction. Since NT-proBNP levels were not significantly increased in documented left ventricular (LV) diastolic dysfunction, this factor may not be sensitive for the detection of latent LV diastolic dysfunction in the early stages of disease progression.

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