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Prognostic impact of Epstein-Barr virus serostatus in patients with nonmalignant hematological disorders undergoing allogeneic hematopoietic cell transplantation: the study of Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation
Affiliations- Department of Pediatric Hematology and Oncology, Jurasz University Hospital, Collegium Medicum UMK Toruń, Bydgoszcz, Poland
- Pediatric Hematology Oncology, Ospedale Donna Bambino, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
- Department of Hematology, Medical University of Białystok, Poland
- Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital, and Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
- Division of Infectious Diseases, Department of Health Sciences, University of Genova, Ospedale Policlinco San Martino, Genova, Italy
- EBMT Data Office, Array, Leiden, The Netherlands
- Hadassah University Hospital, Array, Jerusalem, Israel
- Hopital St. Louis, Array, Paris, France
- Leiden University Hospital, Array, Leiden, The Netherlands
- Hôpital Robert Debre, Array, Paris, France
- King Faisal Specialist Hospital & Research Centre, Array, Riyadh, Saudi Arabia
- Akdeniz University Medical School, Array, Antalya, Turkey
- Institut d'Hematologie et d'Oncologie Pediatrique, Array, Lyon, France
- King Hussein Cancer Centre, Array, Amman, Jordan
- First State Pavlov Medical University of St. Petersburg, Array, St. Petersburg
- Techniciens d'Etude Clinique suivi de patients greffes, Array, Strasbourg, France
- Centre Hospitalier Lyon Sud, Array, Lyon, France
- Cliniques Universitaires St. Luc, Array, Brussels, Belgium
- University Hospital Gasthuisberg, Array, Leuven, Belgium
- University Medical Centre, Array, Utrecht, The Netherlands
- Radboud University Medical Centre, Array, Nijmegen, The Netherlands
- CHU Nantes, Array, Nantes, France
- CHU Bordeaux, Array, Pessac, France
- Sheffield Teaching Hospitals NHS Trust, Array, Sheffield
- Erasmus MC Cancer Institute, Array, Rotterdan, The Netherlands
- Instituto Giannina Gaslini, Genova, Italy
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Abstract
Background
In patients with acute leukemia, lymphoma and chronic malignancies, donor and/or recipient Epstein-Barr virus (EBV) seropositive status increases the risk of development of chronic graft-versus-host disease (cGVHD) after allo-hematopoietic cell transplantation (allo-HCT), while it has no influence on other transplant outcomes. No data are available on the impact of EBV serostatus on transplant outcomes in patients with nonmalignant hematological disorders.
Objective
We analyzed the influence of the recipient's (R) and donor's (D) EBV serostatus on transplant outcomes (overall survival (OS); relapse-free survival (RFS); relapse incidence (RI); nonrelapse mortality (NRM); acute graft-versus-host disease (aGVHD); cGVHD) in patients with nonmalignant hematological disorders undergoing allo-HCT.
Patients and Methods
A total of 2,355 allo-HCTs performed between 1997 and 2016 for acquired bone marrow failure or hemoglobinopathies were included in this retrospective Registry megafile Infectious Diseases Working Party of the European Society of Blood and Marrow Transplantation (IDWP-EBMT) study.
Results
Array
Conclusions
Allo-HCT from EBV-seropositive versus EBV-seronegative donors are at 31% higher risk of cGVHD in patients with nonmalignant hematological disorders undergoing allo-HCT; however this difference is nonsignificant in multivariate analysis.
Abstract
Background
In patients with acute leukemia, lymphoma and chronic malignancies, donor and/or recipient Epstein-Barr virus (EBV) seropositive status increases the risk of development of chronic graft-versus-host disease (cGVHD) after allo-hematopoietic cell transplantation (allo-HCT), while it has no influence on other transplant outcomes. No data are available on the impact of EBV serostatus on transplant outcomes in patients with nonmalignant hematological disorders.
Objective
We analyzed the influence of the recipient's (R) and donor's (D) EBV serostatus on transplant outcomes (overall survival (OS); relapse-free survival (RFS); relapse incidence (RI); nonrelapse mortality (NRM); acute graft-versus-host disease (aGVHD); cGVHD) in patients with nonmalignant hematological disorders undergoing allo-HCT.
Patients and Methods
A total of 2,355 allo-HCTs performed between 1997 and 2016 for acquired bone marrow failure or hemoglobinopathies were included in this retrospective Registry megafile Infectious Diseases Working Party of the European Society of Blood and Marrow Transplantation (IDWP-EBMT) study.
Results
Array
Conclusions
Allo-HCT from EBV-seropositive versus EBV-seronegative donors are at 31% higher risk of cGVHD in patients with nonmalignant hematological disorders undergoing allo-HCT; however this difference is nonsignificant in multivariate analysis.
Keywords
hematopoietic cell transplant; graft-versus-host disease; Epstein-Barr virus; overall survival
About this articleTitle
Prognostic impact of Epstein-Barr virus serostatus in patients with nonmalignant hematological disorders undergoing allogeneic hematopoietic cell transplantation: the study of Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation
Journal
Issue
Pages
73-80
Published online
2020-06-01
Page views
209
Article views/downloads
211
DOI
10.2478/ahp-2020-0015
Bibliographic record
Acta Haematol Pol 2020;51(2):73-80.
Keywords
hematopoietic cell transplant
graft-versus-host disease
Epstein-Barr virus
overall survival
Authors
Jan Styczynski
Gloria Tridello
Lidia Gil
Per Ljungman
Malgorzata Mikulska
Steffie van der Werf
Nina Simone Knelange
Diana Averbuch
Gerard Socié
Hendrik Veelken
Jean-Hugues Dalle
Mahmoud Aljurf
Alphan Kupesiz
Yves Bertrand
Abdelghani Tbakhi
Boris Afanasyev
Bruno Lioure
Hélène Labussière-Wallet
Xavier Poiré
Johan Maertens
Eefke Petersen
Patrice Chevallier
Noel Milpied
John A. Snowden
Ibrahim Yakoub-Agha
Jan Cornelissen
Nicolaas Schaap
Carlo Dufour
Regis Peffault de Latour
Arjan Lankester
Simone Cesaro