open access

Vol 51, No 1 (2020)
ORIGINAL RESEARCH ARTICLE
Submitted: 2019-03-05
Published online: 2020-03-01
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Prediction of survival in non-Hodgkin lymphoma based on markers of systemic inflammation, anemia, hypercoagulability, dyslipidemia, and Eastern Cooperative Oncology Group performance status

Ivan Dzis12, Oleksandra Tomashevska2, Yevhen Dzis2, Zoryana Korytko3
DOI: 10.2478/ahp-2020-0008
·
Acta Haematol Pol 2020;51(1):34-41.
Affiliations
  1. Institute of Blood Pathology and Transfusion Medicine of the National Academy of Medical Sciences (NAMS) of Ukraine, Array, Lviv, Ukraine
  2. Danylo Halytsky Lviv National Medical University, Array, Lviv, Ukraine
  3. Lviv State University of Physical Culture, Array, Lviv, Ukraine

open access

Vol 51, No 1 (2020)
ORIGINAL RESEARCH ARTICLE
Submitted: 2019-03-05
Published online: 2020-03-01

Abstract

Background

The International Prognostic Index and its modifications are used to estimate prognosis in non-Hodgkin lymphoma. However, the outcome is often different in patients with similar index scores.

Aim

The aim of this study was to elaborate a prognostic model for patients with mature B-cell non-Hodgkin lymphoma using a combination of predictive markers.

Material and methods

The study included 45 patients with mature B-cell non-Hodgkin lymphoma. Before the administration of treatment, clinical and laboratory parameters were measured. After the 35-month follow-up period, overall survival was studied in relation to the data obtained at initial examination.

Results

We revealed nine adverse predictive markers for overall survival of enrolled patients: Eastern Cooperative Oncology Group (ECOG) performance status >1; erythrocyte sedimentation rate >30 mm/h; levels of hemoglobin <120 g/L, fibrinogen ≥6 g/L, interleukin-6 ≥2 pg/mL, tumor necrosis factor ≥1.45 pg/mL, soluble fibrin monomer complexes >4 mg/dL, high-density lipoprotein cholesterol <1.03 mmol/L in men, and <1.29 mmol/L in women; and short activated partial thromboplastin time. A prognostic model for the estimation of the risk of death within the ensuing 1.5–2 years in patients with non-Hodgkin lymphoma was constructed.

Conclusion

Markers of inflammation, anemia, hypercoagulability, dyslipidemia, and poor ECOG status are associated with worse survival in patients with mature B-cell non-Hodgkin lymphoma.

Abstract

Background

The International Prognostic Index and its modifications are used to estimate prognosis in non-Hodgkin lymphoma. However, the outcome is often different in patients with similar index scores.

Aim

The aim of this study was to elaborate a prognostic model for patients with mature B-cell non-Hodgkin lymphoma using a combination of predictive markers.

Material and methods

The study included 45 patients with mature B-cell non-Hodgkin lymphoma. Before the administration of treatment, clinical and laboratory parameters were measured. After the 35-month follow-up period, overall survival was studied in relation to the data obtained at initial examination.

Results

We revealed nine adverse predictive markers for overall survival of enrolled patients: Eastern Cooperative Oncology Group (ECOG) performance status >1; erythrocyte sedimentation rate >30 mm/h; levels of hemoglobin <120 g/L, fibrinogen ≥6 g/L, interleukin-6 ≥2 pg/mL, tumor necrosis factor ≥1.45 pg/mL, soluble fibrin monomer complexes >4 mg/dL, high-density lipoprotein cholesterol <1.03 mmol/L in men, and <1.29 mmol/L in women; and short activated partial thromboplastin time. A prognostic model for the estimation of the risk of death within the ensuing 1.5–2 years in patients with non-Hodgkin lymphoma was constructed.

Conclusion

Markers of inflammation, anemia, hypercoagulability, dyslipidemia, and poor ECOG status are associated with worse survival in patients with mature B-cell non-Hodgkin lymphoma.

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Keywords

non-Hodgkin lymphoma; prognosis; hypercoagulability; inflammation; dyslipidemia

About this article
Title

Prediction of survival in non-Hodgkin lymphoma based on markers of systemic inflammation, anemia, hypercoagulability, dyslipidemia, and Eastern Cooperative Oncology Group performance status

Journal

Acta Haematologica Polonica

Issue

Vol 51, No 1 (2020)

Pages

34-41

Published online

2020-03-01

Page views

292

Article views/downloads

347

DOI

10.2478/ahp-2020-0008

Bibliographic record

Acta Haematol Pol 2020;51(1):34-41.

Keywords

non-Hodgkin lymphoma
prognosis
hypercoagulability
inflammation
dyslipidemia

Authors

Ivan Dzis
Oleksandra Tomashevska
Yevhen Dzis
Zoryana Korytko

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