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Road to clinical implementation of CAR-T technology in Poznań
Affiliations- Department of Hematology and Bone Marrow Transplantation, University Hospital of Lord’s Transfiguration, Poznan University of Medical Sciences, Poznan, Poland
- Hospital Pharmacy, University Hospital of Lord’s Transfiguration, Poznan, Poland
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Abstract
The objective of this paper is to present the process of the national and international accreditation leading to the establishment of the first certified chimeric antigen receptor T (CAR-T) Cell Unit in Poland on the basis of the Department of Hematology and Bone Marrow Transplantation in Poznan University of Medical Sciences and first successful CAR-T therapy in Poland. During 12 months from the initial decision to establish the CAR-T Cell Unit to the application of CAR-T cell treatment in the first patient, the center had to undergo the multidisciplinary external and internal training, as well as the adaptation of multiple procedures within the Transplant Unit and Stem Cell Bank. In order to get accreditation for the implementation of CAR-T cell therapy, an initial training of the team involved in handling cellular products and patient care was organized and updated as a continuous process. The Department fulfilled the site-selection international criteria. The first patient diagnosed for refractory/relapsed DLBCL was qualified, and finally CAR-T cells were administered with successful clinical outcome.
Abstract
The objective of this paper is to present the process of the national and international accreditation leading to the establishment of the first certified chimeric antigen receptor T (CAR-T) Cell Unit in Poland on the basis of the Department of Hematology and Bone Marrow Transplantation in Poznan University of Medical Sciences and first successful CAR-T therapy in Poland. During 12 months from the initial decision to establish the CAR-T Cell Unit to the application of CAR-T cell treatment in the first patient, the center had to undergo the multidisciplinary external and internal training, as well as the adaptation of multiple procedures within the Transplant Unit and Stem Cell Bank. In order to get accreditation for the implementation of CAR-T cell therapy, an initial training of the team involved in handling cellular products and patient care was organized and updated as a continuous process. The Department fulfilled the site-selection international criteria. The first patient diagnosed for refractory/relapsed DLBCL was qualified, and finally CAR-T cells were administered with successful clinical outcome.
Keywords
chimeric antigen receptor; CAR-T; axicabtagene ciloleucel; tisagenlecleucel; diffused large B-cell lymphoma
About this articleTitle
Road to clinical implementation of CAR-T technology in Poznań
Journal
Issue
Pages
24-28
Published online
2020-03-01
Page views
338
Article views/downloads
297
DOI
10.2478/ahp-2020-0006
Bibliographic record
Acta Haematol Pol 2020;51(1):24-28.
Keywords
chimeric antigen receptor
CAR-T
axicabtagene ciloleucel
tisagenlecleucel
diffused large B-cell lymphoma
Authors
Dominik Dytfeld
Anna Łojko-Dankowska
Magdalena Matuszak
Anna Wache
Adam Nowicki
Maria Kozłowska-Skrzypczak
Ewa Bembnista
Paula Matuszak
Agnieszka Kubiak
Hanna Jankowiak-Gracz
Agnieszka Nowak-Potoczek
Ksenia Durajczyk
Grażyna Rawicz-Olędzka
Urszula Grzybowska
Jowita Kołtuniak
Iwona Przewoźna
Lidia Gil