open access

Vol 51, No 1 (2020)
ORIGINAL RESEARCH ARTICLE
Published online: 2020-03-01
Submitted: 2020-01-07
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Road to clinical implementation of CAR-T technology in Poznań

Dominik Dytfeld, Anna Łojko-Dankowska, Magdalena Matuszak, Anna Wache, Adam Nowicki, Maria Kozłowska-Skrzypczak, Ewa Bembnista, Paula Matuszak, Agnieszka Kubiak, Hanna Jankowiak-Gracz, Agnieszka Nowak-Potoczek, Ksenia Durajczyk, Grażyna Rawicz-Olędzka, Urszula Grzybowska, Jowita Kołtuniak, Iwona Przewoźna, Lidia Gil
DOI: 10.2478/ahp-2020-0006
·
Acta Haematol Pol 2020;51(1):24-28.

open access

Vol 51, No 1 (2020)
ORIGINAL RESEARCH ARTICLE
Published online: 2020-03-01
Submitted: 2020-01-07

Abstract

The objective of this paper is to present the process of the national and international accreditation leading to the establishment of the first certified chimeric antigen receptor T (CAR-T) Cell Unit in Poland on the basis of the Department of Hematology and Bone Marrow Transplantation in Poznan University of Medical Sciences and first successful CAR-T therapy in Poland. During 12 months from the initial decision to establish the CAR-T Cell Unit to the application of CAR-T cell treatment in the first patient, the center had to undergo the multidisciplinary external and internal training, as well as the adaptation of multiple procedures within the Transplant Unit and Stem Cell Bank. In order to get accreditation for the implementation of CAR-T cell therapy, an initial training of the team involved in handling cellular products and patient care was organized and updated as a continuous process. The Department fulfilled the site-selection international criteria. The first patient diagnosed for refractory/relapsed DLBCL was qualified, and finally CAR-T cells were administered with successful clinical outcome.

Abstract

The objective of this paper is to present the process of the national and international accreditation leading to the establishment of the first certified chimeric antigen receptor T (CAR-T) Cell Unit in Poland on the basis of the Department of Hematology and Bone Marrow Transplantation in Poznan University of Medical Sciences and first successful CAR-T therapy in Poland. During 12 months from the initial decision to establish the CAR-T Cell Unit to the application of CAR-T cell treatment in the first patient, the center had to undergo the multidisciplinary external and internal training, as well as the adaptation of multiple procedures within the Transplant Unit and Stem Cell Bank. In order to get accreditation for the implementation of CAR-T cell therapy, an initial training of the team involved in handling cellular products and patient care was organized and updated as a continuous process. The Department fulfilled the site-selection international criteria. The first patient diagnosed for refractory/relapsed DLBCL was qualified, and finally CAR-T cells were administered with successful clinical outcome.

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Keywords

chimeric antigen receptor; CAR-T; axicabtagene ciloleucel; tisagenlecleucel; diffused large B-cell lymphoma

About this article
Title

Road to clinical implementation of CAR-T technology in Poznań

Journal

Acta Haematologica Polonica

Issue

Vol 51, No 1 (2020)

Pages

24-28

Published online

2020-03-01

DOI

10.2478/ahp-2020-0006

Bibliographic record

Acta Haematol Pol 2020;51(1):24-28.

Keywords

chimeric antigen receptor
CAR-T
axicabtagene ciloleucel
tisagenlecleucel
diffused large B-cell lymphoma

Authors

Dominik Dytfeld
Anna Łojko-Dankowska
Magdalena Matuszak
Anna Wache
Adam Nowicki
Maria Kozłowska-Skrzypczak
Ewa Bembnista
Paula Matuszak
Agnieszka Kubiak
Hanna Jankowiak-Gracz
Agnieszka Nowak-Potoczek
Ksenia Durajczyk
Grażyna Rawicz-Olędzka
Urszula Grzybowska
Jowita Kołtuniak
Iwona Przewoźna
Lidia Gil

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