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The prognostic value of mean platelet volume in cancer patients
Affiliations- Department of Experimental Hematooncology, Medical University of Lublin, Poland
- Hematology Department, St John’s Cancer Center, Lublin, Poland
open access
Abstract
Basic hematological indices, such as platelets count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT), are readily accessible and commonly tested indicators. As platelets play a significant role in many physiological and patho- logical pathways, the abnormalities in these indices inference about irregularities within the organism, such as homeostatic disorders or inflammation. Recent studies revealed a significant impact of MPV on the course and prediction in different types of neoplasms. This review summarizes the most important studies on the impact of MPV levels on outcome and prognosis in different types of cancer conducted in recent years. MPV levels have a significant impact on the length of progression-free survival (PFS) and overall survival (OS) in many types of solid tumors, such as colorectal carcinoma, gastric cancer, pancreatic cancer, esophageal cancer, non-small cell lung cancer, breast cancer, and thyroid cancer. They also affect the prognosis in some lymphoproliferative diseases, such as diffuse large B-cell lymphoma, acute lymphoblastic leukemia, or primary and secondary myelofibrosis.
Abstract
Basic hematological indices, such as platelets count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT), are readily accessible and commonly tested indicators. As platelets play a significant role in many physiological and patho- logical pathways, the abnormalities in these indices inference about irregularities within the organism, such as homeostatic disorders or inflammation. Recent studies revealed a significant impact of MPV on the course and prediction in different types of neoplasms. This review summarizes the most important studies on the impact of MPV levels on outcome and prognosis in different types of cancer conducted in recent years. MPV levels have a significant impact on the length of progression-free survival (PFS) and overall survival (OS) in many types of solid tumors, such as colorectal carcinoma, gastric cancer, pancreatic cancer, esophageal cancer, non-small cell lung cancer, breast cancer, and thyroid cancer. They also affect the prognosis in some lymphoproliferative diseases, such as diffuse large B-cell lymphoma, acute lymphoblastic leukemia, or primary and secondary myelofibrosis.
Keywords
mean platelet volume; platelets; prognosis; neoplasms
About this articleTitle
The prognostic value of mean platelet volume in cancer patients
Journal
Issue
Pages
154-158
Published online
2019-09-28
Page views
173
Article views/downloads
689
DOI
10.2478/ahp-2019-0025
Bibliographic record
Acta Haematol Pol 2019;50(3):154-158.
Keywords
mean platelet volume
platelets
prognosis
neoplasms
Authors
Marta Masternak
Joanna Knap
Krzysztof Giannopoulos