open access

Vol 50, No 3 (2019)
Praca Poglądowa / Review Article
Published online: 2019-09-28
Submitted: 2019-08-01
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The prognostic value of mean platelet volume in cancer patients

Marta Masternak, Joanna Knap, Krzysztof Giannopoulos
DOI: 10.2478/ahp-2019-0025
·
Acta Haematol Pol 2019;50(3):154-158.

open access

Vol 50, No 3 (2019)
Praca Poglądowa / Review Article
Published online: 2019-09-28
Submitted: 2019-08-01

Abstract

Basic hematological indices, such as platelets count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT), are readily accessible and commonly tested indicators. As platelets play a significant role in many physiological and patho- logical pathways, the abnormalities in these indices inference about irregularities within the organism, such as homeostatic disorders or inflammation. Recent studies revealed a significant impact of MPV on the course and prediction in different types of neoplasms. This review summarizes the most important studies on the impact of MPV levels on outcome and prognosis in different types of cancer conducted in recent years. MPV levels have a significant impact on the length of progression-free survival (PFS) and overall survival (OS) in many types of solid tumors, such as colorectal carcinoma, gastric cancer, pancreatic cancer, esophageal cancer, non-small cell lung cancer, breast cancer, and thyroid cancer. They also affect the prognosis in some lymphoproliferative diseases, such as diffuse large B-cell lymphoma, acute lymphoblastic leukemia, or primary and secondary myelofibrosis.

Abstract

Basic hematological indices, such as platelets count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT), are readily accessible and commonly tested indicators. As platelets play a significant role in many physiological and patho- logical pathways, the abnormalities in these indices inference about irregularities within the organism, such as homeostatic disorders or inflammation. Recent studies revealed a significant impact of MPV on the course and prediction in different types of neoplasms. This review summarizes the most important studies on the impact of MPV levels on outcome and prognosis in different types of cancer conducted in recent years. MPV levels have a significant impact on the length of progression-free survival (PFS) and overall survival (OS) in many types of solid tumors, such as colorectal carcinoma, gastric cancer, pancreatic cancer, esophageal cancer, non-small cell lung cancer, breast cancer, and thyroid cancer. They also affect the prognosis in some lymphoproliferative diseases, such as diffuse large B-cell lymphoma, acute lymphoblastic leukemia, or primary and secondary myelofibrosis.

Get Citation

Keywords

mean platelet volume; platelets; prognosis; neoplasms

About this article
Title

The prognostic value of mean platelet volume in cancer patients

Journal

Acta Haematologica Polonica

Issue

Vol 50, No 3 (2019)

Pages

154-158

Published online

2019-09-28

DOI

10.2478/ahp-2019-0025

Bibliographic record

Acta Haematol Pol 2019;50(3):154-158.

Keywords

mean platelet volume
platelets
prognosis
neoplasms

Authors

Marta Masternak
Joanna Knap
Krzysztof Giannopoulos

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