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The role of neuronal apoptosis inhibitory protein (NAIP) in acute myeloid leukemia patients
Affiliations- Department of Hematology, Medical University of Lodz
- Department of Experimental Hematology, Medical University of Lodz, Lodz, Poland
- Department of Surgical Oncology, Copernicus Memorial Hospital, Lodz, Poland
open access
Abstract
Acute myeloid leukemia (AML) is a heterogeneous, highly malignant neoplasm. Apoptosis is a complex process executed by caspases and suppressed by the inhibitor of apoptosis (IAP) family. Neuronal apoptosis inhibitory protein (NAIP), IAP’s member, may play an exceptional role in the mechanisms of tumors’ resistance to chemotherapy. The aims of the study were to assess the expression of NAIP in leukemic blasts of AML patients using flow cytometry and to evaluate its influence on disease outcome. NAIP expression was found in 106 out of 108 patients. A higher complete response rate was associated with a low expression of NAIP, age < 60 yo, and white blood cell count < 20 G/L ( = 0.009, = 0.033, and = 0.076, respectively) in univariate analyses and a low NAIP expression and age < 60 yo ( = 0.025 and = 0.013, respectively) in multivariate analyses. Longer overall survival (OS) in the univariate analysis was influenced by a low NAIP expression, age < 60 yo, and intensive chemotherapy ( = 0.033, < 0.001, and < 0.001, respectively). In the intensively treated group, better OS was observed in patients with age < 60 yo, AML, and a low NAIP expression ( = 0.03, = 0.024, and = 0.07, respectively). In multivariate analysis, longer OS was associated with age < 60 yo ( = 0.009) and AML ( = 0.007). In conclusion, we suggest that NAIP might play an adverse role in response to chemotherapy.
Abstract
Acute myeloid leukemia (AML) is a heterogeneous, highly malignant neoplasm. Apoptosis is a complex process executed by caspases and suppressed by the inhibitor of apoptosis (IAP) family. Neuronal apoptosis inhibitory protein (NAIP), IAP’s member, may play an exceptional role in the mechanisms of tumors’ resistance to chemotherapy. The aims of the study were to assess the expression of NAIP in leukemic blasts of AML patients using flow cytometry and to evaluate its influence on disease outcome. NAIP expression was found in 106 out of 108 patients. A higher complete response rate was associated with a low expression of NAIP, age < 60 yo, and white blood cell count < 20 G/L ( = 0.009, = 0.033, and = 0.076, respectively) in univariate analyses and a low NAIP expression and age < 60 yo ( = 0.025 and = 0.013, respectively) in multivariate analyses. Longer overall survival (OS) in the univariate analysis was influenced by a low NAIP expression, age < 60 yo, and intensive chemotherapy ( = 0.033, < 0.001, and < 0.001, respectively). In the intensively treated group, better OS was observed in patients with age < 60 yo, AML, and a low NAIP expression ( = 0.03, = 0.024, and = 0.07, respectively). In multivariate analysis, longer OS was associated with age < 60 yo ( = 0.009) and AML ( = 0.007). In conclusion, we suggest that NAIP might play an adverse role in response to chemotherapy.
Keywords
acute myeloid leukemia; apoptosis; NAIP
About this articleTitle
The role of neuronal apoptosis inhibitory protein (NAIP) in acute myeloid leukemia patients
Journal
Issue
Pages
74-80
Published online
2019-08-23
Page views
193
Article views/downloads
191
DOI
10.2478/ahp-2019-0011
Bibliographic record
Acta Haematol Pol 2019;50(2):74-80.
Keywords
acute myeloid leukemia
apoptosis
NAIP
Authors
Agnieszka Pluta
Tadeusz Robak
Kamil Brzozowski
Barbara Cebula-Obrzut
Agata Majchrzak
Piotr Pluta
Anna Szmigielska-Kapłon
Olga Grzybowska-Izydorczyk
Magdalena Czemerska
Piotr Stelmach
Piotr Smolewski
Agnieszka Wierzbowska