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Study of CD25 expression on leukemic cells: a prognostic factor in acute myeloid leukemia
Affiliations- Department of Clinical and Chemical Pathology, Faculty of medicine, Alexandria University, Alexandria, Egypt
- Unit of Diabetes and Metabolism, Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt
open access
Abstract
Background
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by a clonal expansion of myeloid blasts. Treatment strategies of patients with AML are based on various prognostic factors, including age and performance status of the patient, as well as cytogenetic and molecular characteristics of the leukemic clone.
Our aim was to study the expression of cluster of differentiation (CD)25 in adult Egyptian patients with newly diagnosed AML and to assess its prognostic relevance.
Methods
This study was conducted on 50 newly diagnosed AML patients at the Hematology Unit, Internal Medicine Department, Alexandria Main University Hospital. All patients were subjected to full history taking, thorough clinical examination, and laboratory investigations, including detection of CD25 expression on blast cells by flow cytometry. Conventional karyotyping was done on 11 patients at the time of diagnosis.
Results
In our study group, 12 patients were positive for CD25 expression, and this positivity was associated with worse overall survival and shorter leukemia-free survival. On evaluating the response to treatment among CD25-positive AML patients with normal karyotype, they had lower complete remission rates and higher relapse and death rates.
Conclusions
Expression of CD25 in AML patients at presentation can be considered a poor independent prognostic factor.
Abstract
Background
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by a clonal expansion of myeloid blasts. Treatment strategies of patients with AML are based on various prognostic factors, including age and performance status of the patient, as well as cytogenetic and molecular characteristics of the leukemic clone.
Our aim was to study the expression of cluster of differentiation (CD)25 in adult Egyptian patients with newly diagnosed AML and to assess its prognostic relevance.
Methods
This study was conducted on 50 newly diagnosed AML patients at the Hematology Unit, Internal Medicine Department, Alexandria Main University Hospital. All patients were subjected to full history taking, thorough clinical examination, and laboratory investigations, including detection of CD25 expression on blast cells by flow cytometry. Conventional karyotyping was done on 11 patients at the time of diagnosis.
Results
In our study group, 12 patients were positive for CD25 expression, and this positivity was associated with worse overall survival and shorter leukemia-free survival. On evaluating the response to treatment among CD25-positive AML patients with normal karyotype, they had lower complete remission rates and higher relapse and death rates.
Conclusions
Expression of CD25 in AML patients at presentation can be considered a poor independent prognostic factor.
Keywords
acute myeloid leukemia; prognosis; CD25 expression; cytogenetics; flow cytometry
About this articleTitle
Study of CD25 expression on leukemic cells: a prognostic factor in acute myeloid leukemia
Journal
Issue
Pages
20-27
Published online
2018-03-30
Page views
144
Article views/downloads
184
DOI
10.2478/ahp-2018-0004
Bibliographic record
Acta Haematol Pol 2018;49(1):20-27.
Keywords
acute myeloid leukemia
prognosis
CD25 expression
cytogenetics
flow cytometry
Authors
Amina H Hassab
Dalia A Nafea
Rania S Swelem
Basma M Ghazal