Managing post-transplant relapse in FLT3-mutated AML with gilteritinib
Abstract
Acute myeloid leukemia (AML) represents 80 % of acute leukemias in the adult population. The mutation of the fms-like tyrosine kinase 3 (FLT3) receptor gene occurs in approximately 30% of patients with newly diagnosed AML, with FLT3-ITD mutation (ITD, internal tandem duplication) accounting for 25% of cases [1]. Approximately 50% of AML patients relapse and 10–40% are refractory to initial first-line treatment [2]. Currently, gilteritinib is the only registered FLT3 inhibitor for relapsed/refractory AML in Europe, which increases the rate of achieving complete responses and prolongs overall survival compared to salvage chemotherapy [3]. This clinical vignette highlights the challenges in the treatment of FLT3 AML patients.
Keywords: acute myeloid leukemiaFLT3-ITD mutationgilteritinibhematopoietic stem cell transplantation
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