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Vol 8, No 1 (2002)
Research paper
Published online: 2002-02-07

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< font face=symbol > a < /font > < font size=1 > 1 < /font > -antitrypsin and elastase in atherosclerosis obliterans

Maria Knapik-Kordecka, Wiesława Doskocz, Barbara Kowal-Gierczak
Acta Angiologica 2002;8(1):23-28.


We included 45 patients (23 women and 22 men) into the study.
The significant increase of a1-antitrypsin (a1AT) and elastase concentration was found in patients with arteriosclerosis obliterans compared to the control group.
Cigarette smoking increased elastase activity, but a1AT level evoluate as a protein, did not change. Both paramethers were depended on the progression of the leg ischaemic in patients with III and IV Fontaine’s degree. Apart from its properties a1-antitrypsin as elastase inhibitor, is included to acute phase proteins and its increased in group of patients suffering from arteriosclerosis obliterans is parallel with fibrinogen (other acute phase protein).
Want of balance between ensyme and its inhibitor increase may be cause vascular damage occuring in arteriosclerosis obliterans.

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