open access

Vol 8, No 1 (2002)
Original papers
Published online: 2002-02-07
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a1-antitrypsin and elastase in atherosclerosis obliterans

Maria Knapik-Kordecka, Wiesława Doskocz, Barbara Kowal-Gierczak
Acta Angiologica 2002;8(1):23-28.

open access

Vol 8, No 1 (2002)
Original papers
Published online: 2002-02-07

Abstract

We included 45 patients (23 women and 22 men) into the study.
The significant increase of a1-antitrypsin (a1AT) and elastase concentration was found in patients with arteriosclerosis obliterans compared to the control group.
Cigarette smoking increased elastase activity, but a1AT level evoluate as a protein, did not change. Both paramethers were depended on the progression of the leg ischaemic in patients with III and IV Fontaine’s degree. Apart from its properties a1-antitrypsin as elastase inhibitor, is included to acute phase proteins and its increased in group of patients suffering from arteriosclerosis obliterans is parallel with fibrinogen (other acute phase protein).
Want of balance between ensyme and its inhibitor increase may be cause vascular damage occuring in arteriosclerosis obliterans.

Abstract

We included 45 patients (23 women and 22 men) into the study.
The significant increase of a1-antitrypsin (a1AT) and elastase concentration was found in patients with arteriosclerosis obliterans compared to the control group.
Cigarette smoking increased elastase activity, but a1AT level evoluate as a protein, did not change. Both paramethers were depended on the progression of the leg ischaemic in patients with III and IV Fontaine’s degree. Apart from its properties a1-antitrypsin as elastase inhibitor, is included to acute phase proteins and its increased in group of patients suffering from arteriosclerosis obliterans is parallel with fibrinogen (other acute phase protein).
Want of balance between ensyme and its inhibitor increase may be cause vascular damage occuring in arteriosclerosis obliterans.
Get Citation

Keywords

a1-antitrypsin; elastase

About this article
Title

a1-antitrypsin and elastase in atherosclerosis obliterans

Journal

Acta Angiologica

Issue

Vol 8, No 1 (2002)

Pages

23-28

Published online

2002-02-07

Bibliographic record

Acta Angiologica 2002;8(1):23-28.

Keywords

a1-antitrypsin
elastase

Authors

Maria Knapik-Kordecka
Wiesława Doskocz
Barbara Kowal-Gierczak

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