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a1-antitrypsin and elastase in atherosclerosis obliterans
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Abstract
The significant increase of a1-antitrypsin (a1AT) and elastase concentration was found in patients with arteriosclerosis obliterans compared to the control group.
Cigarette smoking increased elastase activity, but a1AT level evoluate as a protein, did not change. Both paramethers were depended on the progression of the leg ischaemic in patients with III and IV Fontaine’s degree. Apart from its properties a1-antitrypsin as elastase inhibitor, is included to acute phase proteins and its increased in group of patients suffering from arteriosclerosis obliterans is parallel with fibrinogen (other acute phase protein).
Want of balance between ensyme and its inhibitor increase may be cause vascular damage occuring in arteriosclerosis obliterans.
Abstract
The significant increase of a1-antitrypsin (a1AT) and elastase concentration was found in patients with arteriosclerosis obliterans compared to the control group.
Cigarette smoking increased elastase activity, but a1AT level evoluate as a protein, did not change. Both paramethers were depended on the progression of the leg ischaemic in patients with III and IV Fontaine’s degree. Apart from its properties a1-antitrypsin as elastase inhibitor, is included to acute phase proteins and its increased in group of patients suffering from arteriosclerosis obliterans is parallel with fibrinogen (other acute phase protein).
Want of balance between ensyme and its inhibitor increase may be cause vascular damage occuring in arteriosclerosis obliterans.
Keywords
a1-antitrypsin; elastase
About this articleTitle
a1-antitrypsin and elastase in atherosclerosis obliterans
Journal
Issue
Pages
23-28
Published online
2002-02-07
Bibliographic record
Acta Angiologica 2002;8(1):23-28.
Keywords
a1-antitrypsin
elastase
Authors
Maria Knapik-Kordecka
Wiesława Doskocz
Barbara Kowal-Gierczak