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Vol 8, No 2 (2002)
Review paper
Published online: 2002-03-18
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Iron metabolism, oxidative DNA damage and atherosclerosis

Ryszard Oliński, Marek Jurgowiak
Acta Angiologica 2002;8(2):37-44.

open access

Vol 8, No 2 (2002)
Review papers
Published online: 2002-03-18

Abstract

There are numerous data which pointed out that iron overload may promote development of atherosclerosis. Our recently obtained results suggest a mechanism that may directly link iron overload with atherosclerosis. Specifically, iron overload may favour the persistence of harmful labile (free) iron pool (LIP), which may catalyse generation of the potentially carcinogenic 8-oxodeoxyguanosine (8-oxodG) moiety in the cellular DNA as well as may be responsible for LDL oxidation.

Abstract

There are numerous data which pointed out that iron overload may promote development of atherosclerosis. Our recently obtained results suggest a mechanism that may directly link iron overload with atherosclerosis. Specifically, iron overload may favour the persistence of harmful labile (free) iron pool (LIP), which may catalyse generation of the potentially carcinogenic 8-oxodeoxyguanosine (8-oxodG) moiety in the cellular DNA as well as may be responsible for LDL oxidation.

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Keywords

iron; labile (free) iron pool; free radicals; lipid peroxidation; oxidative DNA damage; atherosclerosis

About this article
Title

Iron metabolism, oxidative DNA damage and atherosclerosis

Journal

Acta Angiologica

Issue

Vol 8, No 2 (2002)

Article type

Review paper

Pages

37-44

Published online

2002-03-18

Page views

1285

Article views/downloads

1499

Bibliographic record

Acta Angiologica 2002;8(2):37-44.

Keywords

iron
labile (free) iron pool
free radicals
lipid peroxidation
oxidative DNA damage
atherosclerosis

Authors

Ryszard Oliński
Marek Jurgowiak

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