open access

Vol 8, No 3 (2002)
Original papers
Published online: 2002-06-27
Get Citation

Trans unsaturated fatty acids are components of atheromatous plaque

Ewa Stachowska, Barbara Dołęgowska, Dariusz Chlubek, Halina Szumiłowicz, Piotr Gutowski, Radosław Turowski, Rabih Samad
Acta Angiologica 2002;8(3):99-104.

open access

Vol 8, No 3 (2002)
Original papers
Published online: 2002-06-27

Abstract

Background. Chromatographic studies on fatty acid composition of atheromatous plaques obtained from 21 patients treated surgically in the Department of Vascular Surgery (Pomeranian Academy of Medicine, Szczecin, Poland) for complications of atherosclerosis of abdominal aorta, iliac or femoral arteries, were carried out.
Aim of the study. The aim of the study was to assess if the trans unsaturated fatty acids (occurring in hardened fats of plant origin) are substantial components of the atheromatous plaques.
Material and methods. Fatty acids were extracted using Folch mixture, saponified in 2% KOH solution and methylated with 14% solution of BF3 in methanol, obtaining fatty acid methyl esters. The analysis of obtained material was carried out with a gas chromatograph Perkin-Elmer 8500, applying Chromed PI software. Correlations between obtained parameters were calculated using the Spearman’s correlation coefficient, taking p < 0.05 as statistically significant.
Results. The presence of varied isomers of fatty acids in the analysed material (among them typical for the hardened plant fats) was established. Elaidic acid (trans-9 C18:1) served as a major trans isomer among monounsaturated fatty acids. The main representative of polyunsaturated fatty acids was one of conjugated diens of linoleic acid: cis-9, trans-11 C18:2.
Conclusions. The results of the study show the relationship between trans unsaturated fatty acids content in the diet and their importance in the metabolism of atheromatous plaque and possible induction of atherogenesis.

Abstract

Background. Chromatographic studies on fatty acid composition of atheromatous plaques obtained from 21 patients treated surgically in the Department of Vascular Surgery (Pomeranian Academy of Medicine, Szczecin, Poland) for complications of atherosclerosis of abdominal aorta, iliac or femoral arteries, were carried out.
Aim of the study. The aim of the study was to assess if the trans unsaturated fatty acids (occurring in hardened fats of plant origin) are substantial components of the atheromatous plaques.
Material and methods. Fatty acids were extracted using Folch mixture, saponified in 2% KOH solution and methylated with 14% solution of BF3 in methanol, obtaining fatty acid methyl esters. The analysis of obtained material was carried out with a gas chromatograph Perkin-Elmer 8500, applying Chromed PI software. Correlations between obtained parameters were calculated using the Spearman’s correlation coefficient, taking p < 0.05 as statistically significant.
Results. The presence of varied isomers of fatty acids in the analysed material (among them typical for the hardened plant fats) was established. Elaidic acid (trans-9 C18:1) served as a major trans isomer among monounsaturated fatty acids. The main representative of polyunsaturated fatty acids was one of conjugated diens of linoleic acid: cis-9, trans-11 C18:2.
Conclusions. The results of the study show the relationship between trans unsaturated fatty acids content in the diet and their importance in the metabolism of atheromatous plaque and possible induction of atherogenesis.
Get Citation

Keywords

trans unsaturated fatty acid; conjugated diens of linoleic acid; atheromatous plaque

About this article
Title

Trans unsaturated fatty acids are components of atheromatous plaque

Journal

Acta Angiologica

Issue

Vol 8, No 3 (2002)

Pages

99-104

Published online

2002-06-27

Bibliographic record

Acta Angiologica 2002;8(3):99-104.

Keywords

trans unsaturated fatty acid
conjugated diens of linoleic acid
atheromatous plaque

Authors

Ewa Stachowska
Barbara Dołęgowska
Dariusz Chlubek
Halina Szumiłowicz
Piotr Gutowski
Radosław Turowski
Rabih Samad

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl