open access

Vol 8, No 4 (2002)
Original papers
Published online: 2002-10-21
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Influence of L-arginine oral supplementation on oxidative stress in patients with intermittent claudication

Maciej Micker, Paweł Chęciński, Anna Jabłecka, Hanna Krauss, Stanisław Zapalski
Acta Angiologica 2002;8(4):137-142.

open access

Vol 8, No 4 (2002)
Original papers
Published online: 2002-10-21

Abstract

Background. It is suggested that the administration of L-arginine to patients with NO deficiency is the rational method both of increasing NO production by the endothelium and decreasing the free radical release. In the last year it was proved that this therapeutic procedure could be successful in patients with atherosclerotic ischaemia of the lower extremities.
Aim of the study. The aim of this study was the estimation of the influence of 28-day L-arginine oral supplementation on NO concentration and the parameters of total antioxidant status (TAS) in patients with intermittent claudication.
Material and methods. 16 patients (8 female and 8 male) were examined diagnosed with atherosclerosis of the lower extremities in Fontaine’s II stage and receiving L-arginine in the dose of 3 x 4 g/day. During the study patients were under accurate clinical observation whose aim was to evaluate drug tolerance and to notice possible adverse effects of L-arginine used in therapy. During the study in 0, after 3 h, and on the 7th, 14th, and 28th day, subjective and objective examinations were conducted with evaluation of the intermittent claudication distance. From every patient the blood samples were taken for the determination of NO concentration and TAS.
Results. After L-arginine treatment in all patients we observed clinical improvement, such as elongation of intermittent claudication distance. We noticed the increase of NO-concentration and higher TAS after 3 h, 7, 14 and 28 days of L-arginine treatment.
Conclusions. Oral supplementation of L-arginine causes a significant increase of NO-concentration and TAS in patients with intermittent claudication.

Abstract

Background. It is suggested that the administration of L-arginine to patients with NO deficiency is the rational method both of increasing NO production by the endothelium and decreasing the free radical release. In the last year it was proved that this therapeutic procedure could be successful in patients with atherosclerotic ischaemia of the lower extremities.
Aim of the study. The aim of this study was the estimation of the influence of 28-day L-arginine oral supplementation on NO concentration and the parameters of total antioxidant status (TAS) in patients with intermittent claudication.
Material and methods. 16 patients (8 female and 8 male) were examined diagnosed with atherosclerosis of the lower extremities in Fontaine’s II stage and receiving L-arginine in the dose of 3 x 4 g/day. During the study patients were under accurate clinical observation whose aim was to evaluate drug tolerance and to notice possible adverse effects of L-arginine used in therapy. During the study in 0, after 3 h, and on the 7th, 14th, and 28th day, subjective and objective examinations were conducted with evaluation of the intermittent claudication distance. From every patient the blood samples were taken for the determination of NO concentration and TAS.
Results. After L-arginine treatment in all patients we observed clinical improvement, such as elongation of intermittent claudication distance. We noticed the increase of NO-concentration and higher TAS after 3 h, 7, 14 and 28 days of L-arginine treatment.
Conclusions. Oral supplementation of L-arginine causes a significant increase of NO-concentration and TAS in patients with intermittent claudication.
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Keywords

L-arginine; endothelium; intermittent claudication; nitric oxide; total antioxidant status

About this article
Title

Influence of L-arginine oral supplementation on oxidative stress in patients with intermittent claudication

Journal

Acta Angiologica

Issue

Vol 8, No 4 (2002)

Pages

137-142

Published online

2002-10-21

Bibliographic record

Acta Angiologica 2002;8(4):137-142.

Keywords

L-arginine
endothelium
intermittent claudication
nitric oxide
total antioxidant status

Authors

Maciej Micker
Paweł Chęciński
Anna Jabłecka
Hanna Krauss
Stanisław Zapalski

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