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Plasma endothelin in unstable angina pectoris
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Abstract
Material and methods. The examined group consisted of 53 patients with unstabled angina, 35 men and 18 women, aged 38 to 78 mean 64.9 ± 10.1 years. Eleven healthy volunteers formed the control group (7 men and 4 women in the age 35 to 63, mean 50.1 ± 9.0 years). ET was determined with ELISA using Biomedica set.
Results. In the plasma of patients with unstable angina, compared with the controls, a statistically significant increased ET-concentration was observed with a large dispersion of values from 0.0 to 11.89 fmol/ml. Also patients with coexisting diabetes type 2 exhibit a significantly higher ET concentration than patients without diabetes. Arterial hypertension and smoking have no influence on ET concentration in patients with unstable angina.
Conclusion. Endothelin responsible for vasoconstruction can play an important role in the pathogenesis of coronary artery disease.
Abstract
Material and methods. The examined group consisted of 53 patients with unstabled angina, 35 men and 18 women, aged 38 to 78 mean 64.9 ± 10.1 years. Eleven healthy volunteers formed the control group (7 men and 4 women in the age 35 to 63, mean 50.1 ± 9.0 years). ET was determined with ELISA using Biomedica set.
Results. In the plasma of patients with unstable angina, compared with the controls, a statistically significant increased ET-concentration was observed with a large dispersion of values from 0.0 to 11.89 fmol/ml. Also patients with coexisting diabetes type 2 exhibit a significantly higher ET concentration than patients without diabetes. Arterial hypertension and smoking have no influence on ET concentration in patients with unstable angina.
Conclusion. Endothelin responsible for vasoconstruction can play an important role in the pathogenesis of coronary artery disease.
Keywords
endothelin; unstable angina pectoris
About this articleTitle
Plasma endothelin in unstable angina pectoris
Journal
Issue
Article type
Research paper
Pages
17-23
Published online
2003-01-08
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896
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1521
Bibliographic record
Acta Angiologica 2003;9(1):17-23.
Keywords
endothelin
unstable angina pectoris
Authors
Maria Kotschy
Ewa Grabarczyk
Teresa Wodyńska
Daniel Kotschy