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Vol 9, No 1 (2003)
Research paper
Published online: 2003-01-08

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Plasma endothelin in unstable angina pectoris

Maria Kotschy, Ewa Grabarczyk, Teresa Wodyńska, Daniel Kotschy
Acta Angiologica 2003;9(1):17-23.


Background. Endothelin (ET) is a potent vasoconstrictor isolated from vascular endothelial cells. The main biological role of ET depends on regulation of vascular tone, blood flow and vascular growth. The aim of our study was to determine ET concentration in unstable angina patients’ plasma.
Material and methods. The examined group consisted of 53 patients with unstabled angina, 35 men and 18 women, aged 38 to 78 mean 64.9 ± 10.1 years. Eleven healthy volunteers formed the control group (7 men and 4 women in the age 35 to 63, mean 50.1 ± 9.0 years). ET was determined with ELISA using Biomedica set.
Results. In the plasma of patients with unstable angina, compared with the controls, a statistically significant increased ET-concentration was observed with a large dispersion of values from 0.0 to 11.89 fmol/ml. Also patients with coexisting diabetes type 2 exhibit a significantly higher ET concentration than patients without diabetes. Arterial hypertension and smoking have no influence on ET concentration in patients with unstable angina.
Conclusion. Endothelin responsible for vasoconstruction can play an important role in the pathogenesis of coronary artery disease.

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