Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Acta Angiologica
MENU
Shortcuts Submit an article Author Guidelines Ahead Of Print Publisher's Jubilee Conference Abstracts Reviewers 2021

open access

Vol 9, No 1 (2003)
Review paper
Published online: 2003-01-08
View PDF (Polish) Download PDF file
Get Citation

Influence of genetic factors on drug treatment efficacy and safety in cardiovascular diseases

Barbara Gawrońska-Szklarz
Acta Angiologica 2003;9(1):1-15.

open access

Vol 9, No 1 (2003)
Review papers
Published online: 2003-01-08

Abstract

Drug treatment is in many cases ineffective. Besides patients who do not respond to the treatment, adverse drug reactions as a consequence of the treatment are a major clinical problem. This review presents clinical implications and molecular mechanisms of genetic polymorphisms of drug metabolizing enzymes (CYP2C9, CYP2D6, CYP3A), drug transporters (P-glycoprotein) and drug receptors, which play a significant role in intersubject variability. Polymorphisms in the genes can affect an individual’s risk of having an adverse drug reaction, or can alter the efficacy of drug treatment in that individual.

Abstract

Drug treatment is in many cases ineffective. Besides patients who do not respond to the treatment, adverse drug reactions as a consequence of the treatment are a major clinical problem. This review presents clinical implications and molecular mechanisms of genetic polymorphisms of drug metabolizing enzymes (CYP2C9, CYP2D6, CYP3A), drug transporters (P-glycoprotein) and drug receptors, which play a significant role in intersubject variability. Polymorphisms in the genes can affect an individual’s risk of having an adverse drug reaction, or can alter the efficacy of drug treatment in that individual.

Full Text:

View PDF (Polish) Download PDF file
Get Citation

Keywords

genetic polymorphism; adverse drug reactions; interactions; cytochrome P450-dependent enzymes; P-glycoprotein; receptors; single nucleotide polymorphism (SNP)

About this article
Title

Influence of genetic factors on drug treatment efficacy and safety in cardiovascular diseases

Journal

Acta Angiologica

Issue

Vol 9, No 1 (2003)

Article type

Review paper

Pages

1-15

Published online

2003-01-08

Page views

645

Article views/downloads

2426

Bibliographic record

Acta Angiologica 2003;9(1):1-15.

Keywords

genetic polymorphism
adverse drug reactions
interactions
cytochrome P450-dependent enzymes
P-glycoprotein
receptors
single nucleotide polymorphism (SNP)

Authors

Barbara Gawrońska-Szklarz

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl