open access

Vol 9, No 1 (2003)
Review papers
Published online: 2003-01-08
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Influence of genetic factors on drug treatment efficacy and safety in cardiovascular diseases

Barbara Gawrońska-Szklarz
Acta Angiologica 2003;9(1):1-15.

open access

Vol 9, No 1 (2003)
Review papers
Published online: 2003-01-08

Abstract

Drug treatment is in many cases ineffective. Besides patients who do not respond to the treatment, adverse drug reactions as a consequence of the treatment are a major clinical problem. This review presents clinical implications and molecular mechanisms of genetic polymorphisms of drug metabolizing enzymes (CYP2C9, CYP2D6, CYP3A), drug transporters (P-glycoprotein) and drug receptors, which play a significant role in intersubject variability. Polymorphisms in the genes can affect an individual’s risk of having an adverse drug reaction, or can alter the efficacy of drug treatment in that individual.

Abstract

Drug treatment is in many cases ineffective. Besides patients who do not respond to the treatment, adverse drug reactions as a consequence of the treatment are a major clinical problem. This review presents clinical implications and molecular mechanisms of genetic polymorphisms of drug metabolizing enzymes (CYP2C9, CYP2D6, CYP3A), drug transporters (P-glycoprotein) and drug receptors, which play a significant role in intersubject variability. Polymorphisms in the genes can affect an individual’s risk of having an adverse drug reaction, or can alter the efficacy of drug treatment in that individual.
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Keywords

genetic polymorphism; adverse drug reactions; interactions; cytochrome P450-dependent enzymes; P-glycoprotein; receptors; single nucleotide polymorphism (SNP)

About this article
Title

Influence of genetic factors on drug treatment efficacy and safety in cardiovascular diseases

Journal

Acta Angiologica

Issue

Vol 9, No 1 (2003)

Pages

1-15

Published online

2003-01-08

Bibliographic record

Acta Angiologica 2003;9(1):1-15.

Keywords

genetic polymorphism
adverse drug reactions
interactions
cytochrome P450-dependent enzymes
P-glycoprotein
receptors
single nucleotide polymorphism (SNP)

Authors

Barbara Gawrońska-Szklarz

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