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Von Willebrand factor and tissue plasminogen activator as vascular endothelial markers in diabetes type 2
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Abstract
Material and methods. The group examined consisted of 60 patients (31 men and 29 women) with diabetes type 2. The mean age was 62 ± 7.9 years, the duration of disease 15 ± 9 years and the mean level of HbA1c 8.76 ± 2.1%. Proliferative retinopathy was observed in 40 patients. All the diabetics were treated with human insulin. The control group consisted of 23 healthy persons aged 48 ± 9 years. The concentration of vWf and t-PA was determined by the ELISA method.
Results. In all type 2 diabetics a significantly higher concentration of von Willebrand factor and tissue plasminogen activator was observed compared with the control group. No differences were noted between diabetics with and without retinopathy. Sex, age, the duration of the diabetes, the concentration of HbA1c and smoking had no significant effect on vWf and t-PA concentrations. In diabetics with coexisting hypertension significantly increased levels of t-PA were noticed.
Conclusion. Increases in vWf and t-PA concentrations indicate vascular endothelial cell damage in type 2 diabetics.
Abstract
Material and methods. The group examined consisted of 60 patients (31 men and 29 women) with diabetes type 2. The mean age was 62 ± 7.9 years, the duration of disease 15 ± 9 years and the mean level of HbA1c 8.76 ± 2.1%. Proliferative retinopathy was observed in 40 patients. All the diabetics were treated with human insulin. The control group consisted of 23 healthy persons aged 48 ± 9 years. The concentration of vWf and t-PA was determined by the ELISA method.
Results. In all type 2 diabetics a significantly higher concentration of von Willebrand factor and tissue plasminogen activator was observed compared with the control group. No differences were noted between diabetics with and without retinopathy. Sex, age, the duration of the diabetes, the concentration of HbA1c and smoking had no significant effect on vWf and t-PA concentrations. In diabetics with coexisting hypertension significantly increased levels of t-PA were noticed.
Conclusion. Increases in vWf and t-PA concentrations indicate vascular endothelial cell damage in type 2 diabetics.
Keywords
von Willebrand factor; tissue plasminogen activator; diabetes type 2
About this articleTitle
Von Willebrand factor and tissue plasminogen activator as vascular endothelial markers in diabetes type 2
Journal
Issue
Article type
Research paper
Pages
63-69
Published online
2003-03-25
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990
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1274
Bibliographic record
Acta Angiologica 2003;9(2):63-69.
Keywords
von Willebrand factor
tissue plasminogen activator
diabetes type 2
Authors
Maria Kotschy
Mirosława Polaszewska-Muszyńska
Wanda Będowska-Gontarz
Zofia Sikorska
Sebastian Moskal