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The effect of buflomedil upon the parameters of vascular flow and blood rheology in patients with obliterative atherosclerosis of lower extremities
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Abstract
Material and methods. Buflomedil was administered orally 2×300 mg for 30 days.
Results. After 30 days of administration of the drug, a significant increase in the index of erythrocyte deformability was observed as well as a decrease in leukocyte adherence, a drop in the total number of leukocyteplatelet aggregates, and an increase in oxygen partial pressure in ischemic extremities.
Conclusion. The observed effect of buflomedil upon the blood rheological parameters suggests a positive effect of this drug on the improvement of microcirculation in patients with the lower limb obliterative atherosclerosis.
Abstract
Material and methods. Buflomedil was administered orally 2×300 mg for 30 days.
Results. After 30 days of administration of the drug, a significant increase in the index of erythrocyte deformability was observed as well as a decrease in leukocyte adherence, a drop in the total number of leukocyteplatelet aggregates, and an increase in oxygen partial pressure in ischemic extremities.
Conclusion. The observed effect of buflomedil upon the blood rheological parameters suggests a positive effect of this drug on the improvement of microcirculation in patients with the lower limb obliterative atherosclerosis.
Keywords
peripheral occlusive arterial disease; hemorheology; buflomedil
About this articleTitle
The effect of buflomedil upon the parameters of vascular flow and blood rheology in patients with obliterative atherosclerosis of lower extremities
Journal
Issue
Article type
Research paper
Pages
123-128
Published online
2003-05-26
Page views
575
Article views/downloads
1465
DOI
10.5603/aa.9933
Bibliographic record
Acta Angiologica 2003;9(3):123-128.
Keywords
peripheral occlusive arterial disease
hemorheology
buflomedil
Authors
Kazimierz Krupiński