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Vol 9, No 3 (2003)
Research paper
Published online: 2003-05-26

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The effect of buflomedil upon the parameters of vascular flow and blood rheology in patients with obliterative atherosclerosis of lower extremities

Kazimierz Krupiński
Acta Angiologica 2003;9(3):123-128.

Abstract

Background. The paper was aimed to evaluate the effect of buflomedil hydrochloride (Buflox, Hexal, Germany) upon the selected hemorheological parameters, such as platelet-leukocyte adherence, deformability of red cells and oxygen pressure in ischemic extremities, measured employing the transcutaneous method in 30 patients with obliterative atherosclerosis of the arteries of lower extremities in stage 2 and 3 according to Fontaine.
Material and methods. Buflomedil was administered orally 2×300 mg for 30 days.
Results. After 30 days of administration of the drug, a significant increase in the index of erythrocyte deformability was observed as well as a decrease in leukocyte adherence, a drop in the total number of leukocyteplatelet aggregates, and an increase in oxygen partial pressure in ischemic extremities.
Conclusion. The observed effect of buflomedil upon the blood rheological parameters suggests a positive effect of this drug on the improvement of microcirculation in patients with the lower limb obliterative atherosclerosis.

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