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Vol 9, No 4 (2003)
Review paper
Published online: 2003-09-26
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The significance of vascular endothelial growth factor in the neoangiogenesis process. The role of hypoxia in the endothelial cells proliferation process and in the formation of collateral circulation

Robert M. Proczka, Jerzy A. Polański, Maciej Małecki, Krzysztof Wikieł
DOI: 10.5603/aa.9924
·
Acta Angiologica 2003;9(4):143-149.

open access

Vol 9, No 4 (2003)
Review papers
Published online: 2003-09-26

Abstract

The formation of new vessels is a complex problem. In this process the key role is played by the vascular-endothelial growth factor (VEGF). It is secreted, among others, by macrophages and endothelial cells. Genes for VEGF are located on the sixth chromosome. Hypoxia is a mandatory signal for the start of the angiogenesis process. Activated through hypoxia, HIF proteins move to the cells nucleus and regulate expression of vascular-endothelial growth factor. VEGF through its receptors on endothelial cells leads to the proliferation of new vessels.

Abstract

The formation of new vessels is a complex problem. In this process the key role is played by the vascular-endothelial growth factor (VEGF). It is secreted, among others, by macrophages and endothelial cells. Genes for VEGF are located on the sixth chromosome. Hypoxia is a mandatory signal for the start of the angiogenesis process. Activated through hypoxia, HIF proteins move to the cells nucleus and regulate expression of vascular-endothelial growth factor. VEGF through its receptors on endothelial cells leads to the proliferation of new vessels.

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Keywords

vascular endothelial growth factor; Ischaemia; VEGF-receptors

About this article
Title

The significance of vascular endothelial growth factor in the neoangiogenesis process. The role of hypoxia in the endothelial cells proliferation process and in the formation of collateral circulation

Journal

Acta Angiologica

Issue

Vol 9, No 4 (2003)

Article type

Review paper

Pages

143-149

Published online

2003-09-26

Page views

577

Article views/downloads

1601

DOI

10.5603/aa.9924

Bibliographic record

Acta Angiologica 2003;9(4):143-149.

Keywords

vascular endothelial growth factor
Ischaemia
VEGF-receptors

Authors

Robert M. Proczka
Jerzy A. Polański
Maciej Małecki
Krzysztof Wikieł

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