open access

Vol 10, No 2 (2004)
Original papers
Published online: 2004-05-10
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Carotid plaque instability in symptomatic carotid disease

Grzegorz Madycki, Walerian Staszkiewicz, Zbigniew Kwietniak
Acta Angiologica 2004;10(2):67-76.

open access

Vol 10, No 2 (2004)
Original papers
Published online: 2004-05-10

Abstract

Background. The currently accepted criteria for carotid endarterectomy are closely related to the severity of carotid artery stenosis, combined with the presence or absence of neurological symptoms. Recently, it has been advocated, that some of the atheromatous lesions not necessarily qualified for surgery may be unstable, thus leading to increased incidence of neurological symptoms. The aim of the study was to determine the relationship between the morphology of the carotid plaque and the risk of increased microembolism during the carotid endarterectomy.
Material and methods. Fifty-two patients were evaluated, while being treated for internal carotid artery stenosis. Among this cohort, 56 endarterectomies were performed (4 patients had bilateral carotid endarterectomies in the period of evaluation. The following data were taken into analysis during this study: the degree of carotid stenosis, morphology of the carotid plaque (GSM); during the surgery, the following elements of blood flow in the medial cerebral artery (MCA) were registered - microembolism, Vav, Vmax and PI. All these parameters were registered using a transcranial Doppler (TCD). The periods of observations were divided into 3 stages (stage I - dissection of arteries, stage II - clamping time, and stage III - after the release of the clamps).
Results. The comparative results of the analysis revealed that in the first group of patients with hipoechogenic, "soft" plaques (GSM < 50) there was a significant increase in the amount of microemboli released during stage I of the operation, than in the II group having hiperechogenic plaques (GSM > 50) - p = 0.002. Also, the cumulated amount of microemboli during all the stages of the operation was significantly higher in group I (p = 0.005).
Conclusions. There is a direct relationship between the carotid plaque echogenicity and the perioperative morbidity related to the amount of microembolism. The results of the study suggest correlation between the plaque morphology and its stability, indicating the necessity for further investigation.

Abstract

Background. The currently accepted criteria for carotid endarterectomy are closely related to the severity of carotid artery stenosis, combined with the presence or absence of neurological symptoms. Recently, it has been advocated, that some of the atheromatous lesions not necessarily qualified for surgery may be unstable, thus leading to increased incidence of neurological symptoms. The aim of the study was to determine the relationship between the morphology of the carotid plaque and the risk of increased microembolism during the carotid endarterectomy.
Material and methods. Fifty-two patients were evaluated, while being treated for internal carotid artery stenosis. Among this cohort, 56 endarterectomies were performed (4 patients had bilateral carotid endarterectomies in the period of evaluation. The following data were taken into analysis during this study: the degree of carotid stenosis, morphology of the carotid plaque (GSM); during the surgery, the following elements of blood flow in the medial cerebral artery (MCA) were registered - microembolism, Vav, Vmax and PI. All these parameters were registered using a transcranial Doppler (TCD). The periods of observations were divided into 3 stages (stage I - dissection of arteries, stage II - clamping time, and stage III - after the release of the clamps).
Results. The comparative results of the analysis revealed that in the first group of patients with hipoechogenic, "soft" plaques (GSM < 50) there was a significant increase in the amount of microemboli released during stage I of the operation, than in the II group having hiperechogenic plaques (GSM > 50) - p = 0.002. Also, the cumulated amount of microemboli during all the stages of the operation was significantly higher in group I (p = 0.005).
Conclusions. There is a direct relationship between the carotid plaque echogenicity and the perioperative morbidity related to the amount of microembolism. The results of the study suggest correlation between the plaque morphology and its stability, indicating the necessity for further investigation.
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Keywords

volunerable carotid plaque; atherosclerosis; ultrasonography

About this article
Title

Carotid plaque instability in symptomatic carotid disease

Journal

Acta Angiologica

Issue

Vol 10, No 2 (2004)

Pages

67-76

Published online

2004-05-10

Bibliographic record

Acta Angiologica 2004;10(2):67-76.

Keywords

volunerable carotid plaque
atherosclerosis
ultrasonography

Authors

Grzegorz Madycki
Walerian Staszkiewicz
Zbigniew Kwietniak

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