open access
The influence of procyanidolic oligomers on plasma anticoagulant activity
open access
Abstract
Material and methods. Twenty-six patients, both surgical and medical, aged 29–86 years, who required antithrombotic prophylaxis for at least 5 days, were included in the study. The patients with higher thrombotic risk received either unfractionated heparin (UFH; 5000 IU bid, s.c., n = 8) or low molecular weight heparin (LMWH; 2850 IU AXa/0.3 mL o.d, s.c., n = 8). The patients with lower thrombotic risk received PO (150 mg bid, p.o., n = 10). In the control group there were age- and sex-matched healthy volunteers, to whom a placebo was administered. Blood samples were drawn before, on the 1, 4, 8 h, as well as on the days 2, 5 after administration of the study medication.
Results. The TFPI concentration did not change significantly from the baseline value at any time, either in patients or in controls. Anti-Xa activity increased at 1 h until day 5 after administration of each study medication. Anti-IIa activity increased at 1 hour and remained elevated until day 5 under UFH and LMWH treatment, but only until day 2 in the PO group. The area under the curve of both anti-Xa and anti-IIa activity was similar in all three study groups but significantly larger as compared to the controls.
Conclusions. Procyanidolic oligomers, like heparin and LMWH, induce anticoagulant response in plasma, but do not release TFPI into the blood.
Abstract
Material and methods. Twenty-six patients, both surgical and medical, aged 29–86 years, who required antithrombotic prophylaxis for at least 5 days, were included in the study. The patients with higher thrombotic risk received either unfractionated heparin (UFH; 5000 IU bid, s.c., n = 8) or low molecular weight heparin (LMWH; 2850 IU AXa/0.3 mL o.d, s.c., n = 8). The patients with lower thrombotic risk received PO (150 mg bid, p.o., n = 10). In the control group there were age- and sex-matched healthy volunteers, to whom a placebo was administered. Blood samples were drawn before, on the 1, 4, 8 h, as well as on the days 2, 5 after administration of the study medication.
Results. The TFPI concentration did not change significantly from the baseline value at any time, either in patients or in controls. Anti-Xa activity increased at 1 h until day 5 after administration of each study medication. Anti-IIa activity increased at 1 hour and remained elevated until day 5 under UFH and LMWH treatment, but only until day 2 in the PO group. The area under the curve of both anti-Xa and anti-IIa activity was similar in all three study groups but significantly larger as compared to the controls.
Conclusions. Procyanidolic oligomers, like heparin and LMWH, induce anticoagulant response in plasma, but do not release TFPI into the blood.
Keywords
procyanidolic oligomers; anti-IIa activity; anti-Xa activity; tissue factor pathway inhibitor; heparin; low molecular weight heparin
About this articleTitle
The influence of procyanidolic oligomers on plasma anticoagulant activity
Journal
Issue
Article type
Research paper
Pages
197-204
Published online
2004-11-23
Page views
763
Article views/downloads
1475
Bibliographic record
Acta Angiologica 2004;10(4):197-204.
Keywords
procyanidolic oligomers
anti-IIa activity
anti-Xa activity
tissue factor pathway inhibitor
heparin
low molecular weight heparin
Authors
Alina Grzywacz
Piotr Psuja
Maria Zozulińska
Jolanta Bednarska
Zofia Turowiecka
Krzysztof Lewandowski
Krystyna Zawilska