open access

Vol 10, No 4 (2004)
Original papers
Published online: 2004-11-23
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The influence of procyanidolic oligomers on plasma anticoagulant activity

Alina Grzywacz, Piotr Psuja, Maria Zozulińska, Jolanta Bednarska, Zofia Turowiecka, Krzysztof Lewandowski, Krystyna Zawilska
Acta Angiologica 2004;10(4):197-204.

open access

Vol 10, No 4 (2004)
Original papers
Published online: 2004-11-23

Abstract

Background. Procyanidolic oligomers (PO) inhibit the degradation of subendothelial connective tissue by collagenase and elastase neutralization. Their efficacy in postphlebitic syndrome and venous insufficiency may suggest an additional systemic action mediated by endothelium. Therefore, the plasma anticoagulant response and the tissue plasma pathway inhibitor (TFPI) release induced by PO was assessed.
Material and methods. Twenty-six patients, both surgical and medical, aged 29–86 years, who required antithrombotic prophylaxis for at least 5 days, were included in the study. The patients with higher thrombotic risk received either unfractionated heparin (UFH; 5000 IU bid, s.c., n = 8) or low molecular weight heparin (LMWH; 2850 IU AXa/0.3 mL o.d, s.c., n = 8). The patients with lower thrombotic risk received PO (150 mg bid, p.o., n = 10). In the control group there were age- and sex-matched healthy volunteers, to whom a placebo was administered. Blood samples were drawn before, on the 1, 4, 8 h, as well as on the days 2, 5 after administration of the study medication.
Results. The TFPI concentration did not change significantly from the baseline value at any time, either in patients or in controls. Anti-Xa activity increased at 1 h until day 5 after administration of each study medication. Anti-IIa activity increased at 1 hour and remained elevated until day 5 under UFH and LMWH treatment, but only until day 2 in the PO group. The area under the curve of both anti-Xa and anti-IIa activity was similar in all three study groups but significantly larger as compared to the controls.
Conclusions. Procyanidolic oligomers, like heparin and LMWH, induce anticoagulant response in plasma, but do not release TFPI into the blood.

Abstract

Background. Procyanidolic oligomers (PO) inhibit the degradation of subendothelial connective tissue by collagenase and elastase neutralization. Their efficacy in postphlebitic syndrome and venous insufficiency may suggest an additional systemic action mediated by endothelium. Therefore, the plasma anticoagulant response and the tissue plasma pathway inhibitor (TFPI) release induced by PO was assessed.
Material and methods. Twenty-six patients, both surgical and medical, aged 29–86 years, who required antithrombotic prophylaxis for at least 5 days, were included in the study. The patients with higher thrombotic risk received either unfractionated heparin (UFH; 5000 IU bid, s.c., n = 8) or low molecular weight heparin (LMWH; 2850 IU AXa/0.3 mL o.d, s.c., n = 8). The patients with lower thrombotic risk received PO (150 mg bid, p.o., n = 10). In the control group there were age- and sex-matched healthy volunteers, to whom a placebo was administered. Blood samples were drawn before, on the 1, 4, 8 h, as well as on the days 2, 5 after administration of the study medication.
Results. The TFPI concentration did not change significantly from the baseline value at any time, either in patients or in controls. Anti-Xa activity increased at 1 h until day 5 after administration of each study medication. Anti-IIa activity increased at 1 hour and remained elevated until day 5 under UFH and LMWH treatment, but only until day 2 in the PO group. The area under the curve of both anti-Xa and anti-IIa activity was similar in all three study groups but significantly larger as compared to the controls.
Conclusions. Procyanidolic oligomers, like heparin and LMWH, induce anticoagulant response in plasma, but do not release TFPI into the blood.
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Keywords

procyanidolic oligomers; anti-IIa activity; anti-Xa activity; tissue factor pathway inhibitor; heparin; low molecular weight heparin

About this article
Title

The influence of procyanidolic oligomers on plasma anticoagulant activity

Journal

Acta Angiologica

Issue

Vol 10, No 4 (2004)

Pages

197-204

Published online

2004-11-23

Bibliographic record

Acta Angiologica 2004;10(4):197-204.

Keywords

procyanidolic oligomers
anti-IIa activity
anti-Xa activity
tissue factor pathway inhibitor
heparin
low molecular weight heparin

Authors

Alina Grzywacz
Piotr Psuja
Maria Zozulińska
Jolanta Bednarska
Zofia Turowiecka
Krzysztof Lewandowski
Krystyna Zawilska

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