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Selected endothelial markers in atherosclerotic plaques and plasma of patients undergoing carotid endarterectomy
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Abstract
Material and methods. Thirty-eight patients (20 symptomatic, 18 asymptomatic) undergoing carotid endarterectomy were enrolled in this study. The concentration of selected endothelial cell factors in extracts of carotid plaques and plasma was measured with enzyme immunoassay (ELISA). The concentration of these factors was calculated per mg of protein (mg/P).
Results. In extracts of carotid plaques, a much higher concentration of TM, ET and sel. E and P was observed than in patient’s plasma. The concentration of examined parameters in plaques was uninfluenced by sex, age, arterial hypertension, the degree of arterial stenosis, hyperlipidemia and smoking. Only diabetes increased its level in plaques.
Conclusions: All evaluated factors TM, ET, sel. E and P are the components of the carotid plaque. Its concentrations are much higher in plaques than in plasma. Therefore, they take part in the pathogenesis of carotid plaque formation and arterial stenosis.
Abstract
Material and methods. Thirty-eight patients (20 symptomatic, 18 asymptomatic) undergoing carotid endarterectomy were enrolled in this study. The concentration of selected endothelial cell factors in extracts of carotid plaques and plasma was measured with enzyme immunoassay (ELISA). The concentration of these factors was calculated per mg of protein (mg/P).
Results. In extracts of carotid plaques, a much higher concentration of TM, ET and sel. E and P was observed than in patient’s plasma. The concentration of examined parameters in plaques was uninfluenced by sex, age, arterial hypertension, the degree of arterial stenosis, hyperlipidemia and smoking. Only diabetes increased its level in plaques.
Conclusions: All evaluated factors TM, ET, sel. E and P are the components of the carotid plaque. Its concentrations are much higher in plaques than in plasma. Therefore, they take part in the pathogenesis of carotid plaque formation and arterial stenosis.
Keywords
carotid atheriosclerotic plaque; endothelial cells markers
About this articleTitle
Selected endothelial markers in atherosclerotic plaques and plasma of patients undergoing carotid endarterectomy
Journal
Issue
Article type
Research paper
Pages
173-180
Published online
2004-11-23
Page views
795
Article views/downloads
1059
DOI
10.5603/aa.9905
Bibliographic record
Acta Angiologica 2004;10(4):173-180.
Keywords
carotid atheriosclerotic plaque
endothelial cells markers
Authors
Maria Kotschy
Aleksandra Knapik-Bieniek
Arkadiusz Migdalski
Daniel Kotschy
Arkadiusz Jawień