Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Acta Angiologica
MENU
Shortcuts Submit an article Author Guidelines Ahead Of Print Publisher's Jubilee Conference Abstracts Reviewers 2022

open access

Vol 11, No 2 (2005)
Research paper
Published online: 2005-05-19
View PDF (Polish) Download PDF file
Get Citation

The usefulness of assessing the serum levels of S-100 protein in patients with ischemic stroke

Danuta Kokocińska, Paweł Gruenpeter, Przemysław Jałowiecki, Robert Partyka, Piotr Wieczorek, Łukasz Michalecki, Izabela Chanek, Jerzy Jarząb, Lech Cierpka
Acta Angiologica 2005;11(2):105-113.

open access

Vol 11, No 2 (2005)
Original papers
Published online: 2005-05-19

Abstract

Background. It is important to identify new biochemical markers of strokes to monitor and predict the neurological outcome, as well as to elucidate the multiple molecular mechanisms after ischemic brain infarction. Recently, an elevation of S-100 protein in serum were reported in strokes, but still, different biochemical techniques must be developed as soon as possible in order to help us to improve effective treatment. Modern neuroradiological techniques help to predict the outcome; however, repeating neuroradiological imaging is impractical. The aim of the study was to evaluate the serum levels of S-100 protein after brain infarction in correlation with clinical data and prognosis.
Material and methods. S-100 protein serum levels were determined in 47 patients with an acute ischemic brain infarction in the first day (within 12 hours after the onset of symptoms) and sex and age matched control subjects. The clinical status was documented using the Scandinavian Stroke Scale. The functional deficit 4 weeks after stroke onset was scored with the Barthel Index. A cranial computed tomography (CCT) was performed after 2 days.
Results. Elevated concentrations of S-100 protein were observed in patients with strokes. The S-100 concentrations in serum were significantly higher in patients with severe neurological deficits at the time of admission and correlated with the functional prognosis.
Conclusions. The measurement of S-100 protein in serum is useful to diagnose and predict the outcome in patients after brain infarction.

Abstract

Background. It is important to identify new biochemical markers of strokes to monitor and predict the neurological outcome, as well as to elucidate the multiple molecular mechanisms after ischemic brain infarction. Recently, an elevation of S-100 protein in serum were reported in strokes, but still, different biochemical techniques must be developed as soon as possible in order to help us to improve effective treatment. Modern neuroradiological techniques help to predict the outcome; however, repeating neuroradiological imaging is impractical. The aim of the study was to evaluate the serum levels of S-100 protein after brain infarction in correlation with clinical data and prognosis.
Material and methods. S-100 protein serum levels were determined in 47 patients with an acute ischemic brain infarction in the first day (within 12 hours after the onset of symptoms) and sex and age matched control subjects. The clinical status was documented using the Scandinavian Stroke Scale. The functional deficit 4 weeks after stroke onset was scored with the Barthel Index. A cranial computed tomography (CCT) was performed after 2 days.
Results. Elevated concentrations of S-100 protein were observed in patients with strokes. The S-100 concentrations in serum were significantly higher in patients with severe neurological deficits at the time of admission and correlated with the functional prognosis.
Conclusions. The measurement of S-100 protein in serum is useful to diagnose and predict the outcome in patients after brain infarction.

Full Text:

View PDF (Polish) Download PDF file
Get Citation

Keywords

brain infarction; S-100 protein

About this article
Title

The usefulness of assessing the serum levels of S-100 protein in patients with ischemic stroke

Journal

Acta Angiologica

Issue

Vol 11, No 2 (2005)

Article type

Research paper

Pages

105-113

Published online

2005-05-19

Page views

1462

Article views/downloads

1472

Bibliographic record

Acta Angiologica 2005;11(2):105-113.

Keywords

brain infarction
S-100 protein

Authors

Danuta Kokocińska
Paweł Gruenpeter
Przemysław Jałowiecki
Robert Partyka
Piotr Wieczorek
Łukasz Michalecki
Izabela Chanek
Jerzy Jarząb
Lech Cierpka

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl