open access

Vol 13, No 4 (2007)
Original papers
Published online: 2007-09-26
Get Citation

Multidirectional assessment of medical treatment influence on lower limb perfusion in patients suffering from obliterative atheromatosis

Jacek Mikosiński, Tomasz Lesiak, Marian Brocki, Zbigniew Maziarz, Mariusz Gadzicki, Wiesław Tryniszewski
Acta Angiologica 2007;13(4):144-155.

open access

Vol 13, No 4 (2007)
Original papers
Published online: 2007-09-26

Abstract

Background. Chronic lower-limb ischaemia has been the subject of several studies; however, most of them do not give a comparison between vascular flow at rest and vascular flow after exercise. Nuclear medicine is vested with methods and programmes allowing the solution of this matter. The aim of this study was to define, with the use of radioisotopic methods, the perfusion disturbances of lower limb muscles at rest and after exercise in patients with arterial obliterative atheromatosis, and to compare the results with the standard methods assessing lower limb perfusion, as well as to assess the influence of the medical treatment on the analyzed parameters of the perfusion.
Material and methods. The material included 35 patients, medically treated because of lower limbs ischaemia. The study covered patients who, at the time of admission, reported feeling cold, numbness and intermittent claudication at 30 to 500 m For group classification, all the patients underwent USG-Doppler examination with a colour option. The patients with the second degree according to Foutaine (IIa, IIb), whose claudication distance ranged between 30 and 500 m, were included in the study. Medical treatment included modification of the factors and combined pharmacotherapy, and defining factors: ankle-brachial, femoral-tibial and femoral-ankle. Radioisotopic examinations of lower limb perfusion at rest and after exercise were performed with the use of a gamma camera according to our own method and an ALLP programme defining the perfusion indicators in the examined muscles.
Conclusions. 1. A six-month period of medical treatment, including combined pharmacological treatment, causes a slight increase of lower limb perfusion, expressed mainly by an increase of the ankle-brachial index, decrease of the femoral-ankle and femoral-tibial indexes, and improvement of the speed of flow in all examined arteries. 2. Radioisotopic examination of muscle perfusion is a very precise and beneficial examination defining the changes in perfusion in the lower limbs (tibias and femora) at rest and after exercise. The obtained perfusion indexes give precise information about the scale of changes in microcirculation and allow the effects of the medical treatment to be monitored. 3. The radioisotopic method has completed previous diagnostics of lower limb perfusion disturbances in patients suffering from arterial obliterative atheromatosis.

Abstract

Background. Chronic lower-limb ischaemia has been the subject of several studies; however, most of them do not give a comparison between vascular flow at rest and vascular flow after exercise. Nuclear medicine is vested with methods and programmes allowing the solution of this matter. The aim of this study was to define, with the use of radioisotopic methods, the perfusion disturbances of lower limb muscles at rest and after exercise in patients with arterial obliterative atheromatosis, and to compare the results with the standard methods assessing lower limb perfusion, as well as to assess the influence of the medical treatment on the analyzed parameters of the perfusion.
Material and methods. The material included 35 patients, medically treated because of lower limbs ischaemia. The study covered patients who, at the time of admission, reported feeling cold, numbness and intermittent claudication at 30 to 500 m For group classification, all the patients underwent USG-Doppler examination with a colour option. The patients with the second degree according to Foutaine (IIa, IIb), whose claudication distance ranged between 30 and 500 m, were included in the study. Medical treatment included modification of the factors and combined pharmacotherapy, and defining factors: ankle-brachial, femoral-tibial and femoral-ankle. Radioisotopic examinations of lower limb perfusion at rest and after exercise were performed with the use of a gamma camera according to our own method and an ALLP programme defining the perfusion indicators in the examined muscles.
Conclusions. 1. A six-month period of medical treatment, including combined pharmacological treatment, causes a slight increase of lower limb perfusion, expressed mainly by an increase of the ankle-brachial index, decrease of the femoral-ankle and femoral-tibial indexes, and improvement of the speed of flow in all examined arteries. 2. Radioisotopic examination of muscle perfusion is a very precise and beneficial examination defining the changes in perfusion in the lower limbs (tibias and femora) at rest and after exercise. The obtained perfusion indexes give precise information about the scale of changes in microcirculation and allow the effects of the medical treatment to be monitored. 3. The radioisotopic method has completed previous diagnostics of lower limb perfusion disturbances in patients suffering from arterial obliterative atheromatosis.
Get Citation

Keywords

obliterative atheromatosis; scintigraphy; perfusion

About this article
Title

Multidirectional assessment of medical treatment influence on lower limb perfusion in patients suffering from obliterative atheromatosis

Journal

Acta Angiologica

Issue

Vol 13, No 4 (2007)

Pages

144-155

Published online

2007-09-26

Bibliographic record

Acta Angiologica 2007;13(4):144-155.

Keywords

obliterative atheromatosis
scintigraphy
perfusion

Authors

Jacek Mikosiński
Tomasz Lesiak
Marian Brocki
Zbigniew Maziarz
Mariusz Gadzicki
Wiesław Tryniszewski

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl