open access

Vol 15, No 2 (2009)
Original papers
Published online: 2009-05-11
Get Citation

Inherited thrombophilia in patients with chronic venous leg ulceration

Adam Wiszniewski, Ksenia Bykowska, Wojciech Jaśkowiak, Radosław Bilski, Jerzy Ratajczak
Acta Angiologica 2009;15(2):61-83.

open access

Vol 15, No 2 (2009)
Original papers
Published online: 2009-05-11

Abstract


Background. Chronic venous ulceration (CVU), which is the end stage of the complex of symptoms of chronic venous disease (CVD), is a significant health problem. One of the major causes of CVU is deep venous thrombosis (DVT). Thrombophilia is diagnosed in about 41% of patients with a history of DVT. The aim of this study was to assess the prevalence of inherited thrombophilia (IT) in patients with CVU.
Material and methods. During 24 months, a group of 110 patients with CVU and a group of 110 healthy people were studied. There were no significant differences in age or sex between the two groups. All patients in the study group were assessed as C5 or C6 according to CEAP classification. The patients underwent clinical and Doppler ultrasonography examination. Blood was drawn for antithrombin (AT), protein C (PC) and S (PS), factor V Leiden (VL), prothrombin G20210A (PT), LA, and ACL.
Results. From the group of 110 CVU patients, IT was diagnosed in 33 (30%), LA in 5 (4.5%), and ACL in 12 (10.9%).
Conclusions. Our results suggest that IT might be one of several important thrombotic risk factors which lead to CVU.

Abstract


Background. Chronic venous ulceration (CVU), which is the end stage of the complex of symptoms of chronic venous disease (CVD), is a significant health problem. One of the major causes of CVU is deep venous thrombosis (DVT). Thrombophilia is diagnosed in about 41% of patients with a history of DVT. The aim of this study was to assess the prevalence of inherited thrombophilia (IT) in patients with CVU.
Material and methods. During 24 months, a group of 110 patients with CVU and a group of 110 healthy people were studied. There were no significant differences in age or sex between the two groups. All patients in the study group were assessed as C5 or C6 according to CEAP classification. The patients underwent clinical and Doppler ultrasonography examination. Blood was drawn for antithrombin (AT), protein C (PC) and S (PS), factor V Leiden (VL), prothrombin G20210A (PT), LA, and ACL.
Results. From the group of 110 CVU patients, IT was diagnosed in 33 (30%), LA in 5 (4.5%), and ACL in 12 (10.9%).
Conclusions. Our results suggest that IT might be one of several important thrombotic risk factors which lead to CVU.
Get Citation

Keywords

inherited thrombophilia; antiphospholipid antibodies; venous ulcer; deep vein thrombosis

About this article
Title

Inherited thrombophilia in patients with chronic venous leg ulceration

Journal

Acta Angiologica

Issue

Vol 15, No 2 (2009)

Pages

61-83

Published online

2009-05-11

Bibliographic record

Acta Angiologica 2009;15(2):61-83.

Keywords

inherited thrombophilia
antiphospholipid antibodies
venous ulcer
deep vein thrombosis

Authors

Adam Wiszniewski
Ksenia Bykowska
Wojciech Jaśkowiak
Radosław Bilski
Jerzy Ratajczak

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl