open access

Vol 15, No 2 (2009)
Research paper
Published online: 2009-05-11
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Inherited thrombophilia in patients with chronic venous leg ulceration

Adam Wiszniewski, Ksenia Bykowska, Wojciech Jaśkowiak, Radosław Bilski, Jerzy Ratajczak
DOI: 10.5603/aa.9805
·
Acta Angiologica 2009;15(2):61-83.

open access

Vol 15, No 2 (2009)
Original papers
Published online: 2009-05-11

Abstract


Background. Chronic venous ulceration (CVU), which is the end stage of the complex of symptoms of chronic venous disease (CVD), is a significant health problem. One of the major causes of CVU is deep venous thrombosis (DVT). Thrombophilia is diagnosed in about 41% of patients with a history of DVT. The aim of this study was to assess the prevalence of inherited thrombophilia (IT) in patients with CVU.
Material and methods. During 24 months, a group of 110 patients with CVU and a group of 110 healthy people were studied. There were no significant differences in age or sex between the two groups. All patients in the study group were assessed as C5 or C6 according to CEAP classification. The patients underwent clinical and Doppler ultrasonography examination. Blood was drawn for antithrombin (AT), protein C (PC) and S (PS), factor V Leiden (VL), prothrombin G20210A (PT), LA, and ACL.
Results. From the group of 110 CVU patients, IT was diagnosed in 33 (30%), LA in 5 (4.5%), and ACL in 12 (10.9%).
Conclusions. Our results suggest that IT might be one of several important thrombotic risk factors which lead to CVU.

Abstract


Background. Chronic venous ulceration (CVU), which is the end stage of the complex of symptoms of chronic venous disease (CVD), is a significant health problem. One of the major causes of CVU is deep venous thrombosis (DVT). Thrombophilia is diagnosed in about 41% of patients with a history of DVT. The aim of this study was to assess the prevalence of inherited thrombophilia (IT) in patients with CVU.
Material and methods. During 24 months, a group of 110 patients with CVU and a group of 110 healthy people were studied. There were no significant differences in age or sex between the two groups. All patients in the study group were assessed as C5 or C6 according to CEAP classification. The patients underwent clinical and Doppler ultrasonography examination. Blood was drawn for antithrombin (AT), protein C (PC) and S (PS), factor V Leiden (VL), prothrombin G20210A (PT), LA, and ACL.
Results. From the group of 110 CVU patients, IT was diagnosed in 33 (30%), LA in 5 (4.5%), and ACL in 12 (10.9%).
Conclusions. Our results suggest that IT might be one of several important thrombotic risk factors which lead to CVU.
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Keywords

inherited thrombophilia; antiphospholipid antibodies; venous ulcer; deep vein thrombosis

About this article
Title

Inherited thrombophilia in patients with chronic venous leg ulceration

Journal

Acta Angiologica

Issue

Vol 15, No 2 (2009)

Article type

Research paper

Pages

61-83

Published online

2009-05-11

Page views

790

Article views/downloads

1560

DOI

10.5603/aa.9805

Bibliographic record

Acta Angiologica 2009;15(2):61-83.

Keywords

inherited thrombophilia
antiphospholipid antibodies
venous ulcer
deep vein thrombosis

Authors

Adam Wiszniewski
Ksenia Bykowska
Wojciech Jaśkowiak
Radosław Bilski
Jerzy Ratajczak

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