Vol 30, No 3 (2024)
Review paper
Published online: 2024-10-24
Heat-shock protein 27 (HSP27) not just a biomarker of cardiac and renal diseases
DOI: 10.5603/aa.97350
Acta Angiologica 2024;30(3):106-111.
Abstract
Heat-shock proteins (HSPs) are a large family of conserved chaperone proteins which provide cell protection
from various forms of stress including inflammation, hypoxia, ischaemia, and apoptosis. Heat-shock protein
27 (HSP27) is a member of a small molecular weight HSP family and it has recently been connected with
cardiac and renal disorders. Several studies stated that HSP27 can be a reliable predictor of cardiac events in
patients with chronic heart failure. Moreover, there is a strong inverse relationship between HSP27 level and
atherosclerosis. Interestingly, the HSP27 level in atherosclerosis plaques was significantly lower compared to
healthy arteries. Additionally, HSP27 was linked with atrial fibrillation (AF) and acute chest pain. Various studies
also reported HSP27’s usefulness in renal disorders. HSP27 seems to be an independent predictor of not only
cardiovascular mortality but also sudden cardiac death (SCD) among haemodialysed (HD) patients. Collaterally
HSP27 was proposed as a marker of chronic kidney disease, contrast-induced acute kidney injury (AKI) as well
as AKI associated with liver ischaemia-reperfusion injury. Observations from studies conducted to date suggest
that HSP27 may be a valuable marker for cardiovascular and nephrological diseases and even a possible therapeutic
target. However, to fully understand the role of HSP27 in these diseases, further studies are required.
Keywords: heat-shock protein 27atherosclerosisacute kidney injuryatrial fibrillation
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