open access

Vol 22, No 4 (2016)
Review papers
Published online: 2017-03-14
Get Citation

Biomechanical factors in Finite Element Analysis of abdominal aortic aneurysms

Zuzanna Domagala, Hubert Stepak, Pawel Drapikowski, Lukasz Dzieciuchowicz, Malgorzata Pyda, Katarzyna Karmelita-Katulska, Grzegorz Oszkinis
DOI: 10.5603/AA.2016.0016
·
Acta Angiologica 2016;22(4):164-171.

open access

Vol 22, No 4 (2016)
Review papers
Published online: 2017-03-14

Abstract

The abdominal aortic aneurysm is tenth most common cause of death in Western countries. Since maximal transverse diameter as indication for surgical interventions is often criticized, biomechanics of the aneurysm has been studied to develop new criteria for a treatment. The Finite Element Method is being utilized to predict vessel stability. Computer simulations are proven to have high accuracy of rupture risk assessment, although the impact of all incorporated factors is still not fully known. The objective of this paper is to review the most commonly used biomechanical components of computer analysis, including geometry of the vessel, mechanical properties of the wall, thrombus and calcification, their impact on rupture risk, and methods of modelling blood pressure. Comprehension and precise assessment of biomechanics of aneurysm in terms of Finite Element Analysis have high potential in clinical management of abdominal aortic aneurysm.

Abstract

The abdominal aortic aneurysm is tenth most common cause of death in Western countries. Since maximal transverse diameter as indication for surgical interventions is often criticized, biomechanics of the aneurysm has been studied to develop new criteria for a treatment. The Finite Element Method is being utilized to predict vessel stability. Computer simulations are proven to have high accuracy of rupture risk assessment, although the impact of all incorporated factors is still not fully known. The objective of this paper is to review the most commonly used biomechanical components of computer analysis, including geometry of the vessel, mechanical properties of the wall, thrombus and calcification, their impact on rupture risk, and methods of modelling blood pressure. Comprehension and precise assessment of biomechanics of aneurysm in terms of Finite Element Analysis have high potential in clinical management of abdominal aortic aneurysm.

Get Citation

Keywords

Finite Element Analysis, abdominal aortic aneurysm (AAA), biomechanics of abdominal aortic aneurysm (AAA), computer simulation

About this article
Title

Biomechanical factors in Finite Element Analysis of abdominal aortic aneurysms

Journal

Acta Angiologica

Issue

Vol 22, No 4 (2016)

Pages

164-171

Published online

2017-03-14

DOI

10.5603/AA.2016.0016

Bibliographic record

Acta Angiologica 2016;22(4):164-171.

Keywords

Finite Element Analysis
abdominal aortic aneurysm (AAA)
biomechanics of abdominal aortic aneurysm (AAA)
computer simulation

Authors

Zuzanna Domagala
Hubert Stepak
Pawel Drapikowski
Lukasz Dzieciuchowicz
Malgorzata Pyda
Katarzyna Karmelita-Katulska
Grzegorz Oszkinis

References (62)
  1. Johnston K, Rutherford R, Tilson M, et al. Suggested standards for reporting on arterial aneurysms. Journal of Vascular Surgery. 1991; 13(3): 452–458.
  2. Żukowski M, Biernawska J, Kotfis K, et al. Perioperative factors influencing the mortality of elective abdominal aorta aneurysm repair. Acta Angiol. 2013; 19: 1–8.
  3. Fillinger M. Who should we operate on and how do we decide: predicting rupture and survival in patients with aortic aneurysm. Semin Vasc Surg. 2007; 20(2): 121–127.
  4. Nicholls SC, Gardner JB, Meissner MH, et al. Rupture in small abdominal aortic aneurysms. J Vasc Surg. 1998; 28(5): 884–888.
  5. Thompson SG, Brown LC, Sweeting MJ, et al. Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness. Health Technol Assess. 2013; 17(41): 1–118.
  6. Powell JT, Gotensparre SM, Sweeting MJ, et al. Rupture rates of small abdominal aortic aneurysms: a systematic review of the literature. Eur J Vasc Endovasc Surg. 2011; 41(1): 2–10.
  7. Hua J, Mower WR. Simple geometric characteristics fail to reliably predict abdominal aortic aneurysm wall stresses. J Vasc Surg. 2001; 34(2): 308–315.
  8. Sacks MS, Vorp DA, Raghavan ML, et al. In vivo three-dimensional surface geometry of abdominal aortic aneurysms. Ann Biomed Eng. 1999; 27(4): 469–479.
  9. Schriefl AJ, Zeindlinger G, Pierce DM, et al. Determination of the layer-specific distributed collagen fibre orientations in human thoracic and abdominal aortas and common iliac arteries. J R Soc Interface. 2012; 9(71): 1275–1286.
  10. Di Martino ES, Bohra A, Vande Geest JP, et al. Biomechanical properties of ruptured versus electively repaired abdominal aortic aneurysm wall tissue. J Vasc Surg. 2006; 43(3): 570–576.
  11. Raghavan ML, Kratzberg J, Castro de Tolosa EM, et al. Regional distribution of wall thickness and failure properties of human abdominal aortic aneurysm. J Biomech. 2006; 39(16): 3010–3016.
  12. Reeps C, Maier A, Pelisek J, et al. Measuring and modeling patient-specific distributions of material properties in abdominal aortic aneurysm wall. Biomech Model Mechanobiol. 2013; 12(4): 717–733.
  13. Mohammad NF, Nassriq MN, Saidatul A (2009) Analysis of blood flow, pressure and velocity in a stented abdominal aortic aneurysm model. Proceedings of International Conference on Applications and Design in Mechanical Engineering (iCADME). 2009.
  14. Raut SS, Jana A, De Oliveira V, et al. The importance of patient-specific regionally varying wall thickness in abdominal aortic aneurysm biomechanics. J Biomech Eng. 2013; 135(8): 81010.
  15. Raghavan ML, Vorp DA, Federle MP, et al. Wall stress distribution on three-dimensionally reconstructed models of human abdominal aortic aneurysm. J Vasc Surg. 2000; 31(4): 760–769.
  16. Doyle BJ, Cloonan AJ, Walsh MT, et al. Identification of rupture locations in patient-specific abdominal aortic aneurysms using experimental and computational techniques. J Biomech. 2010; 43(7): 1408–1416.
  17. Fillinger MF, Marra SP, Raghavan ML, et al. Prediction of rupture risk in abdominal aortic aneurysm during observation: wall stress versus diameter. J Vasc Surg. 2003; 37(4): 724–732.
  18. Venkatasubramaniam AK, Fagan MJ, Mehta T, et al. A comparative study of aortic wall stress using finite element analysis for ruptured and non-ruptured abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2004; 28(2): 168–176.
  19. Mower WR, Quiñones WJ, Gambhir SS. Effect of intraluminal thrombus on abdominal aortic aneurysm wall stress. J Vasc Surg. 1997; 26(4): 602–608.
  20. Wang DHJ, Makaroun MS, Webster MW, et al. Effect of intraluminal thrombus on wall stress in patient-specific models of abdominal aortic aneurysm. J Vasc Surg. 2002; 36(3): 598–604.
  21. Thubrikar MJ, Robicsek F, Labrosse M, et al. Effect of thrombus on abdominal aortic aneurysm wall dilation and stress. J Cardiovasc Surg (Torino). 2003; 44(1): 67–77.
  22. Inzoli F, Boschetti F, Zappa M, et al. Biomechanical factors in abdominal aortic aneurysm rupture. Eur J Vasc Surg. 1993; 7(6): 667–674.
  23. Vorp DA, Lee PC, Wang DH, et al. Association of intraluminal thrombus in abdominal aortic aneurysm with local hypoxia and wall weakening. J Vasc Surg. 2001; 34(2): 291–299.
  24. Kazi M, Thyberg J, Religa P, et al. Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall. J Vasc Surg. 2003; 38(6): 1283–1292.
  25. Thompson JF, Mullee MA, Bell PR, et al. Intraoperative heparinisation, blood loss and myocardial infarction during aortic aneurysm surgery: a Joint Vascular Research Group study. Eur J Vasc Endovasc Surg. 1996; 12(1): 86–90.
  26. Newman KM, Jean-Claude J, Li H, et al. Cellular localization of matrix metalloproteinases in the abdominal aortic aneurysm wall. J Vasc Surg. 1994; 20(5): 814–820.
  27. Campbell EJ, Wald MS. Hypoxic injury to human alveolar macrophages accelerates release of previously bound neutrophil elastase. Implications for lung connective tissue injury including pulmonary emphysema. Am Rev Respir Dis. 1983; 127(5): 631–635.
  28. Kowalewski R, Panek B, Pałka J, et al. Assessment of some of the factors involved in collagen metabolism in the abdominal aortic aneurysm wall. Acta Angiol. 2007; 13: 56–64.
  29. Herrick SE, Ireland GW, Simon D, et al. Venous ulcer fibroblasts compared with normal fibroblasts show differences in collagen but not fibronectin production under both normal and hypoxic conditions. J Invest Dermatol. 1996; 106(1): 187–193.
  30. Steinbrech DS, Longaker MT, Mehrara BJ, et al. Fibroblast response to hypoxia: the relationship between angiogenesis and matrix regulation. J Surg Res. 1999; 84(2): 127–133.
  31. Stenbaek J, Kalin B, Swedenborg J. Growth of thrombus may be a better predictor of rupture than diameter in patients with abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2000; 20(5): 466–469.
  32. Speelman L, Bohra A, Bosboom EM, et al. Effects of wall calcifications in patient-specific wall stress analyses of abdominal aortic aneurysms. J Biomech Eng. 2007; 129(1): 105–109.
  33. Li ZY, U-King-Im J, Tang TY, et al. Impact of calcification and intraluminal thrombus on the computed wall stresses of abdominal aortic aneurysm. J Vasc Surg. 2008; 47(5): 928–935.
  34. Maier A, Gee MW, Reeps C, et al. Impact of calcifications on patient-specific wall stress analysis of abdominal aortic aneurysms. Biomech Model Mechanobiol. 2010; 9(5): 511–521.
  35. Fillinger MF, Racusin J, Baker RK, et al. Anatomic characteristics of ruptured abdominal aortic aneurysm on conventional CT scans: Implications for rupture risk. J Vasc Surg. 2004; 39(6): 1243–1252.
  36. Elger DF, Blackketter DM, Budwig RS, et al. The influence of shape on the stresses in model abdominal aortic aneurysms. J Biomech Eng. 1996; 118(3): 326–332.
  37. Raghavan ML, Vorp DA. Toward a biomechanical tool to evaluate rupture potential of abdominal aortic aneurysm: identification of a finite strain constitutive model and evaluation of its applicability. J Biomech. 2000; 33(4): 475–482.
  38. Thubrikar MJ, al-Soudi J, Robicsek F. Wall stress studies of abdominal aortic aneurysm in a clinical model. Ann Vasc Surg. 2001; 15(3): 355–366.
  39. Scotti CM, Shkolnik AD, Muluk SC, et al. Fluid-structure interaction in abdominal aortic aneurysms: effects of asymmetry and wall thickness. Biomed Eng Online. 2005; 4: 64–86.
  40. Fillinger MF, Raghavan ML, Marra SP, et al. In vivo analysis of mechanical wall stress and abdominal aortic aneurysm rupture risk. J Vasc Surg. 2002; 36(3): 589–597.
  41. Venkatasubramaniam AK, Fagan MJ, Mehta T, et al. A comparative study of aortic wall stress using finite element analysis for ruptured and non-ruptured abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2004; 28(2): 168–176.
  42. O'Leary SA, Healey DA, Kavanagh EG, et al. The biaxial biomechanical behavior of abdominal aortic aneurysm tissue. Ann Biomed Eng. 2014; 42(12): 2440–2450.
  43. Vande Geest JP, Sacks MS, Vorp DA. The effects of aneurysm on the biaxial mechanical behavior of human abdominal aorta. J Biomech. 2006; 39(7): 1324–1334.
  44. Wang DH, Makaroun M, Webster MW, et al. Mechanical properties and microstructure of intraluminal thrombus from abdominal aortic aneurysm. J Biomech Eng. 2001; 123(6): 536–539.
  45. van Dam EA, Dams SD, Peters GWM, et al. Non-linear viscoelastic behavior of abdominal aortic aneurysm thrombus. Biomech Model Mechanobiol. 2008; 7(2): 127–137.
  46. Ayyalasomayajula A, Vande Geest JP, Simon BR. Porohyperelastic finite element modeling of abdominal aortic aneurysms. J Biomech Eng. 2010; 132(10): 104502.
  47. Polzer S, Bursa J. Poroelastic Model of Intraluminal Thrombus in FEA of Aortic Aneurysm. IFMBE Proceedings. 2010: 763–767.
  48. Marra SP, Daghlian CP, Fillinger MF, et al. Elemental composition, morphology and mechanical properties of calcified deposits obtained from abdominal aortic aneurysms. Acta Biomater. 2006; 2(5): 515–520.
  49. Loree HM, Grodzinsky AJ, Park SY, et al. Static circumferential tangential modulus of human atherosclerotic tissue. J Biomech. 1994; 27(2): 195–204.
  50. Di Martino ES, Guadagni G, Fumero A, et al. Fluid-structure interaction within realistic three-dimensional models of the aneurysmatic aorta as a guidance to assess the risk of rupture of the aneurysm. Med Eng Phys. 2001; 23(9): 647–655.
  51. Vande Geest JP, Sacks MS, Vorp DA. A planar biaxial constitutive relation for the luminal layer of intra-luminal thrombus in abdominal aortic aneurysms. J Biomech. 2006; 39(13): 2347–2354.
  52. Huang H, Virmani R, Younis H, et al. The impact of calcification on the biomechanical stability of atherosclerotic plaques. Circulation. 2001; 103(8): 1051–1056.
  53. Gasser TC, Auer M, Labruto F, et al. Biomechanical rupture risk assessment of abdominal aortic aneurysms: model complexity versus predictability of finite element simulations. Eur J Vasc Endovasc Surg. 2010; 40(2): 176–185.
  54. Larsson E, Labruto F, Gasser TC, et al. Analysis of aortic wall stress and rupture risk in patients with abdominal aortic aneurysm with a gender perspective. J Vasc Surg. 2011; 54(2): 295–299.
  55. de Putter S, Wolters BJ, Rutten MCM, et al. Patient-specific initial wall stress in abdominal aortic aneurysms with a backward incremental method. J Biomech. 2007; 40(5): 1081–1090.
  56. Raghavan ML, Ma B, Fillinger MF. Non-invasive determination of zero-pressure geometry of arterial aneurysms. Ann Biomed Eng. 2006; 34(9): 1414–1419.
  57. Speelman L, Bosboom EMH, Schurink GWH, et al. Initial stress and nonlinear material behavior in patient-specific AAA wall stress analysis. J Biomech. 2009; 42(11): 1713–1719.
  58. Chandra S, Raut SS, Jana A, et al. Fluid-structure interaction modeling of abdominal aortic aneurysms: the impact of patient-specific inflow conditions and fluid/solid coupling. J Biomech Eng. 2013; 135(8): 81001.
  59. Scotti C, Finol E. Compliant biomechanics of abdominal aortic aneurysms: A fluid–structure interaction study. Computers & Structures. 2007; 85(11-14): 1097–1113.
  60. Peattie RA, Riehle TJ, Bluth EI. Pulsatile flow in fusiform models of abdoiminal aortic aneurysms: flow fields, velocity patterns and flow-induced wall stresses. J Biomech Eng. 2004; 126(4): 438–446.
  61. Fillinger MF, Marra SP, Raghavan ML, et al. Prediction of rupture risk in abdominal aortic aneurysm during observation: wall stress versus diameter. J Vasc Surg. 2003; 37(4): 724–732.
  62. Georgakarakos E, Ioannou CV, Kamarianakis Y, et al. The role of geometric parameters in the prediction of abdominal aortic aneurysm wall stress. Eur J Vasc Endovasc Surg. 2010; 39(1): 42–48.

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl