open access

Vol 20, No 3 (2014)
Review papers
Published online: 2014-12-10

The use of cilostazol in intermittent claudication in patients with peripheral arterial disease

Paweł Wierzchowski, Arkadiusz Migdalski, Arkadiusz Jawień
Acta Angiologica 2014;20(3):101-105.

open access

Vol 20, No 3 (2014)
Review papers
Published online: 2014-12-10

Abstract

Intermittent claudication is the most frequent one symptom of peripheral arterial disease (PAD). Extending the distance free from pain is achieved by surgical treatment, endovascular and appropriate pharmaco­therapy. Phosphodiesterase III (PDE) are a group of drugs that have a very strong anti-aggregation effect. In addition, they have vasodilator activity, lipid-lowering and anti-proliferative what makes them the subject of numerous scientific publications. Cilostazol is the best studied PDE inhibitor. Though not devoid of side effects the drug has been shown to influence the extension of claudication distance. Compared to the placebo and pentoxifylline significantly affect the maximum claudication distance (MWD) and pain-free distance (PWD). In addition, effectively prevents restenosis after endovascular treatment of coronary and peripheral vessels. Cilostazol may also be an alternative in the case of the development of resistance to conventional anti-platelet agents. TASC II guidelines recommend the use of 3–6 months treatment with cilostazol in alleviating the symptoms of intermittent claudication. Treatment for monitoring and verification requires specialist.

Keywords

intermittent claudication, cilostazol, lower limb ischemia, peripheral arterial disease

About this article
Title

The use of cilostazol in intermittent claudication in patients with peripheral arterial disease

Journal

Acta Angiologica

Issue

Vol 20, No 3 (2014)

Pages

101-105

Published online

2014-12-10

Bibliographic record

Acta Angiologica 2014;20(3):101-105.

Keywords

intermittent claudication
cilostazol
lower limb ischemia
peripheral arterial disease

Authors

Paweł Wierzchowski
Arkadiusz Migdalski
Arkadiusz Jawień

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl