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Influence of low and moderate grade leg ischaemia on the skin microcirculation parameters in peripheral arterial occlusive disease patients
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Abstract
Introduction. The aim of the study was to characterize the changes in the microcirculation in patients with varying severity of atherosclerotic ischaemia of the lower limbs (PAOD).
Material and methods. The study included 27 healthy subjects, 79 patients with PAOD category 0 and 1 according to the Rutherford classification, and 137 patients with PAOD category 3 and 4. The study evaluated cutaneous blood flow, flowmotion bonds, percutaneous partial pressure of oxygen and flow-mediated vasodilation.
Results. Even mild PAOD exhibits a worse systemic vascular function expressed as a reduction in the scope of flow-mediated vasodilation, and locally in TcpO2 decrease. Increase in local changes in advanced forms of PAOD were observed as further reduction in TcpO2 and a drastic reduction or exhaustion of the functional microcirculatory reserve. Among the evaluated risk factors for atherosclerosis only diabetes and smoking significantly modified perfusion, which resulted in a significant decrease in the values of vasodilation and TcpO2.
Conclusions. The study revealed the occurrence of adverse changes in microcirculation, also in patients with poorly discernible signs of limb ischaemia. It can be assumed that these may also occur in the patients who underwent a haemodynamically effective revascularization.
Abstract
Introduction. The aim of the study was to characterize the changes in the microcirculation in patients with varying severity of atherosclerotic ischaemia of the lower limbs (PAOD).
Material and methods. The study included 27 healthy subjects, 79 patients with PAOD category 0 and 1 according to the Rutherford classification, and 137 patients with PAOD category 3 and 4. The study evaluated cutaneous blood flow, flowmotion bonds, percutaneous partial pressure of oxygen and flow-mediated vasodilation.
Results. Even mild PAOD exhibits a worse systemic vascular function expressed as a reduction in the scope of flow-mediated vasodilation, and locally in TcpO2 decrease. Increase in local changes in advanced forms of PAOD were observed as further reduction in TcpO2 and a drastic reduction or exhaustion of the functional microcirculatory reserve. Among the evaluated risk factors for atherosclerosis only diabetes and smoking significantly modified perfusion, which resulted in a significant decrease in the values of vasodilation and TcpO2.
Conclusions. The study revealed the occurrence of adverse changes in microcirculation, also in patients with poorly discernible signs of limb ischaemia. It can be assumed that these may also occur in the patients who underwent a haemodynamically effective revascularization.
Keywords
skin microcirculation, flowmotion, atherosclerotic limb ischaemia, percutaneous partial pressure of oxygen, flow-mediated vasodilation
About this articleTitle
Influence of low and moderate grade leg ischaemia on the skin microcirculation parameters in peripheral arterial occlusive disease patients
Journal
Issue
Article type
Research paper
Pages
133-140
Published online
2015-03-20
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815
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1378
Bibliographic record
Acta Angiologica 2014;20(4):133-140.
Keywords
skin microcirculation
flowmotion
atherosclerotic limb ischaemia
percutaneous partial pressure of oxygen
flow-mediated vasodilation
Authors
Katarzyna Pawlaczyk-Gabriel
Marcin Gabriel
Zbigniew Krasiński
Łukasz Dzieciuchowicz
Michał Stanisić
Zofia Gabriel
Małgorzata Olejniczak-Nowakowska
Tomasz Urbanek